MicroRNA therapeutics and nucleic acid nano-delivery systems in bacterial infection: A review

Z Li, Z Lei, Y Cai, DB Cheng, T Sun - Journal of Materials Chemistry B, 2023 - pubs.rsc.org
Bacteria that have worked with humans for thousands of years pose a major threat to human
health even today, as drug resistance has become a prominent problem. Compared to …

Inhibition of bacterial RNA polymerase function and protein–protein interactions: a promising approach for next-generation antibacterial therapeutics

J Ye, CH Kan, X Yang, C Ma - RSC Medicinal Chemistry, 2024 - pubs.rsc.org
The increasing prevalence of multidrug-resistant pathogens necessitates the urgent
development of new antimicrobial agents with innovative modes of action for the next …

Sorangicin A Is Active against Chlamydia in Cell Culture, Explanted Fallopian Tubes, and Topical In Vivo Treatment

S Graspeuntner, K Koethke, C Scholz, L Semmler… - Antibiotics, 2023 - mdpi.com
Current treatment of Chlamydia trachomatis using doxycycline and azithromycin introduces
detrimental side effects on the host's microbiota. As a potential alternative treatment, the …

An Optimized Workflow for the Discovery of New Antimicrobial Compounds Targeting Bacterial RNA Polymerase Complex Formation

A Caputo, S Sartini, E Levati, I Minato, GM Elisi… - Antibiotics, 2022 - mdpi.com
Bacterial resistance represents a major health problem worldwide and there is an urgent
need to develop first-in-class compounds directed against new therapeutic targets. We …