Beyond the bulk: disclosing the life of single microbial cells

K Rosenthal, V Oehling, C Dusny… - FEMS microbiology …, 2017 - academic.oup.com
Microbial single cell analysis has led to discoveries that are beyond what can be resolved
with population-based studies. It provides a pristine view of the mechanisms that organize …

Scaling laws governing stochastic growth and division of single bacterial cells

S Iyer-Biswas, CS Wright, JT Henry… - Proceedings of the …, 2014 - National Acad Sciences
Uncovering the quantitative laws that govern the growth and division of single cells remains
a major challenge. Using a unique combination of technologies that yields unprecedented …

First‐passage processes in cellular biology

S Iyer‐Biswas, A Zilman - Advances in chemical physics, 2016 - Wiley Online Library
Many aspects of the behaviors of physical, chemical, and biological systems can be
understood simply in terms of the dynamics of the averaged state variables and their …

Mechanical feedback promotes bacterial adaptation to antibiotics

S Banerjee, K Lo, N Ojkic, R Stephens, NF Scherer… - Nature Physics, 2021 - nature.com
To maximize their fitness, cells must be able to respond effectively to stresses. This demands
making trade-offs between processes that conserve resources to promote survival, and …

ATP-responsive biomolecular condensates tune bacterial kinase signaling

S Saurabh, TN Chong, C Bayas, PD Dahlberg… - Science …, 2022 - science.org
Biomolecular condensates formed via liquid-liquid phase separation enable spatial and
temporal organization of enzyme activity. Phase separation in many eukaryotic condensates …

A one-dimensional three-state run-and-tumble model with a 'cell cycle'

D Breoni, FJ Schwarzendahl, R Blossey… - The European Physical …, 2022 - Springer
We study a one-dimensional three-state run-and-tumble model motivated by the bacterium
Caulobacter crescentus which displays a cell cycle between two non-proliferating mobile …

Spatiotemporal choreography of chromosome and megaplasmids in the Sinorhizobium meliloti cell cycle

B Frage, J Döhlemann, M Robledo… - Molecular …, 2016 - Wiley Online Library
A considerable share of bacterial species maintains multipartite genomes. Precise
coordination of genome replication and segregation with cell growth and division is vital for …

Super-exponential growth and stochastic size dynamics in rod-like bacteria

A Cylke, S Banerjee - Biophysical Journal, 2023 - cell.com
Proliferating bacterial cells exhibit stochastic growth and size dynamics, but the regulation of
noise in bacterial growth and morphogenesis remains poorly understood. A quantitative …

The conserved polarity factor PodJ1 impacts multiple cell envelope‐associated functions in Sinorhizobium meliloti

AT Fields, CS Navarrete, AZ Zare, Z Huang… - Molecular …, 2012 - Wiley Online Library
Although diminutive in size, bacteria possess highly diverse and spatially confined cellular
structures. Two related alphaproteobacteria, Sinorhizobium meliloti and Caulobacter …

Intergenerational continuity of cell shape dynamics in Caulobacter crescentus

CS Wright, S Banerjee, S Iyer-Biswas, S Crosson… - Scientific reports, 2015 - nature.com
We investigate the intergenerational shape dynamics of single Caulobacter crescentus cells
using a novel combination of imaging techniques and theoretical modeling. We determine …