Cubosomes as an emerging platform for drug delivery: A review of the state of the art

MAS Abourehab, MJ Ansari, A Singh… - Journal of Materials …, 2022 - pubs.rsc.org
Lipid-based drug-delivery nanoparticles, including non-lamellar-type, mesophasic
nanostructured materials of lyotropic liquid crystals (LLCs), have been a topic of interest for …

Nanotechnology for enhanced nose-to-brain drug delivery in treating neurological diseases

Q Huang, Y Chen, W Zhang, X Xia, H Li, M Qin… - Journal of Controlled …, 2024 - Elsevier
Despite the increasing global incidence of brain disorders, achieving sufficient delivery
towards the central nervous system (CNS) remains a formidable challenge in terms of …

Intranasal in situ gelling liquid crystal for delivery of resveratrol ameliorates memory and neuroinflammation in Alzheimer's disease

B Fonseca-Santos, CA Cazarin, PB da Silva… - … , Biology and Medicine, 2023 - Elsevier
Alzheimer's disease (AD) is an illness that affects people aged 65 or older and affects
around 6.5 million in the United States. Resveratrol is a chemical obtained from natural …

Nose to brain delivery of Astragaloside IV by β-Asarone modified chitosan nanoparticles for multiple sclerosis therapy

X Zhao, L Sun, J Wang, X Xu, S Ni, M Liu… - International Journal of …, 2023 - Elsevier
Multiple sclerosis (MS), an autoimmune disease, has been considered an inflammatory
disorder of the central nervous system (CNS) with demyelination and axonal damage …

Progress and challenges of lyotropic liquid crystalline nanoparticles for innovative therapies

AVP Silvestrini, BW Debiasi, FG Praça… - International Journal of …, 2022 - Elsevier
Since the late 20th century, we have witnessed a growing and substantial advance in
nanomedicine, in part due to the development of multifunctional and multimodal …

Core-shell lipoplexes inducing active macropinocytosis promote intranasal delivery of c-Myc siRNA for treatment of glioblastoma

Y Hu, K Jiang, D Wang, S Yao, L Lu, H Wang, J Song… - Acta Biomaterialia, 2022 - Elsevier
Glioblastoma is the most common and aggressive primary brain tumor, whose malignancy is
closely correlated with elevated proto-oncogene c-myc. Intranasal administration emerges …

The prospective of liquid crystals in nano formulations for drug delivery systems

R Bala, RK Sindhu, B Kaundle, R Madaan… - Journal of Molecular …, 2021 - Elsevier
In recent years, liquid crystals dosage forms has gained immense potential as
pharmaceutical drug delivery system. Liquid crystals (LCs) are also known as mesophase …

Evaluation of the skin permeation-enhancing abilities of newly developed water-soluble self-assembled liquid crystal formulations based on hexosomes

WR Kadhum, GL See, M Alhijjaj, MM Kadhim, FJ Arce… - Crystals, 2022 - mdpi.com
The present study aimed to develop polyethylene glycol–liquid crystals (PEG-LC) ointment
formulations, assess their formulation characteristics, and establish their biocompatibility …

Tailoring the self-assembly of lipid-based lyotropic liquid crystalline mesophases with biocompatible ionic liquid aqueous solutions

M El Mohamad, Q Han, CJ Drummond… - Materials Today …, 2022 - Elsevier
Interest in lipid-based lyotropic liquid crystalline nanoparticles (LCNPs) as drug delivery
vehicles continues to grow, owing to their unique structural features. The structure of these …

Tetrahedral Framework Nucleic Acids as an Efficient Nasal‐to‐Brain Delivery Carrier via Neural Transport Pathways

G Zhang, Y Gao, L Yao, L Huang, Y Yao… - Advanced Functional …, 2025 - Wiley Online Library
In the development of nasal‐to‐brain (N2B) drug delivery systems, the key challenge lies in
penetrating the mucus, crossing the nasal epithelial barrier, and achieving broad distribution …