The tumor suppressor p53 has established functions in cancer. Specifically, it has been
shown to cause cell-cycle arrest and apoptosis in response to DNA damage. It is also one of …

Aromatase is the enzyme that catalyzes the conversion of androgens to estrogens. Initial
studies of its enzymatic activity and function took place in an environment focused on …

There is increasing concern that certain chemicals in the environment can cause endocrine
disruption in exposed humans and wildlife. Investigations of potential effects on endocrine …

One in eight women will develop breast cancer over their lifetime making it the most
common female cancer. The cause of breast cancer is multifactorial and includes hormonal …

Estrogen exposure represents the major known risk factor for development of breast cancer
in women and is implicated in the development of prostate cancer in men. Human breast …

Breast cancer is the second highest prevalent cancer globally after lung cancer with 2.09
million cases during 2018. Adults about 1.9 billion were overweight and over 650 million out …

A significant contributing factor in the development of breast cancer is the estrogens. The
synthesis of estrogens is primarily facilitated by aromatase (CYP19), a cytochrome P450 …

Estrogen is a major factor in the development of breast cancer. In situ estrogen production
by aromatase/estrogen synthetase in breast cancer plays a dominant role in tumor …

Postoperative radiotherapy, which forms part of breastconserving therapy, may not need to
encompass the whole breast. Apart from the consumption of huge resources and patients' …

Intratumoral Aromatase in Human Breast, Endometrial, and Ovarian Malignancies* | Endocrine
Reviews | Oxford Academic Skip to Main Content Advertisement Oxford Academic Journals …