Eosinophils derive from the bone marrow and circulate at low levels in the blood in healthy
individuals. These granulated cells preferentially leave the circulation and marginate to …

Abstract THE IDIOPATHIC hypereosinophilic syndrome (HES) is a leukoproliferative
disorder, or more likely disorders, marked by a sustained overproduction of eosinophils. The …

The induction of optimal systemic antitumor immunity involves the priming of both CD4+ and
CD8+ T cells specific for tumor-associated antigens. The role of CD4+ T helper cells (Th) in …

Macrophage inflammatory protein-1α (MIP-1α) and MIP-1β are highly related members of
the CC chemokine subfamily. Despite their structural similarities, MIP-1α and MIP-1β show …

Eosinophils are leukocytes resident in mucosal tissues. During T‐helper 2 (Th2)‐type
inflammation, eosinophils are recruited from bone marrow and blood to the sites of immune …

Asthma is a complex chronic inflammatory disease of the airways that involves the activation
of many inflammatory and structural cells, all of which release inflammatory mediators that …

Cytokines are usually extracellular signalling proteins, usually less than 80 kD in size, and
many are glycosylated. They are produced by many diVerent cell types that are involved in …

This best-selling resource has a worldwide reputation as the leader in its field. Focusing on
human immunology and biology, while also reporting on scientific experimentation and …

Background: In most nasal polyps, tissue eosinophilia is a striking finding, the pathologic
mechanism of which is not understood. Objective: This study was performed to investigate a …

Over the years, the role of the eosinophil in asthma and allergic processes has been
disputed. Recent human experiments using a humanised monoclonal antibody to interleukin …