Membership testing in markov equivalence classes via independence queries

J Zhang, K Shiragur, C Uhler - International Conference on …, 2024 - proceedings.mlr.press
Understanding causal relationships between variables is a fundamental problem with broad
impact in numerous scientific fields. While extensive research has been dedicated to\emph …

Discovering gene regulatory networks of multiple phenotypic groups using dynamic Bayesian networks

P Suter, J Kuipers, N Beerenwinkel - Briefings in Bioinformatics, 2022 - academic.oup.com
Abstract Dynamic Bayesian networks (DBNs) can be used for the discovery of gene
regulatory networks (GRNs) from time series gene expression data. Here, we suggest a …

Adaptivity complexity for causal graph discovery

D Choo, K Shiragur - Uncertainty in Artificial Intelligence, 2023 - proceedings.mlr.press
Causal discovery from interventional data is an important problem, where the task is to
design an interventional strategy that learns the hidden ground truth causal graph $ G (V, E) …

New metrics and search algorithms for weighted causal DAGs

D Choo, K Shiragur - International Conference on Machine …, 2023 - proceedings.mlr.press
Recovering causal relationships from data is an important problem. Using observational
data, one can typically only recover causal graphs up to a Markov equivalence class and …

NetREm Network Regression Embeddings reveal cell-type transcription factor coordination for gene regulation

S Khullar, X Huang, R Ramesh, J Svaren… - Bioinformatics …, 2024 - academic.oup.com
Motivation Transcription factor (TF) coordination plays a key role in gene regulation via
direct and/or indirect protein-protein interactions (PPIs) and DNA co-binding to regulatory …

Using empirical biological knowledge to infer regulatory networks from multi-omics data

A Pačínková, V Popovici - BMC bioinformatics, 2022 - Springer
Background Integration of multi-omics data can provide a more complex view of the
biological system consisting of different interconnected molecular components, the crucial …

Causal Discovery with Fewer Conditional Independence Tests

K Shiragur, J Zhang, C Uhler - arXiv preprint arXiv:2406.01823, 2024 - arxiv.org
Many questions in science center around the fundamental problem of understanding causal
relationships. However, most constraint-based causal discovery algorithms, including the …

Learning massive interpretable gene regulatory networks of the human brain by merging Bayesian networks

N Bernaola, M Michiels, P Larrañaga… - PLOS Computational …, 2023 - journals.plos.org
We present the Fast Greedy Equivalence Search (FGES)-Merge, a new method for learning
the structure of gene regulatory networks via merging locally learned Bayesian networks …

Causal Discovery under Off-Target Interventions

D Choo, K Shiragur, C Uhler - arXiv preprint arXiv:2402.08229, 2024 - arxiv.org
Causal graph discovery is a significant problem with applications across various disciplines.
However, with observational data alone, the underlying causal graph can only be recovered …

Membership Testing in Markov Equivalence Classes via Independence Query Oracles

J Zhang, K Shiragur, C Uhler - arXiv preprint arXiv:2403.05759, 2024 - arxiv.org
Understanding causal relationships between variables is a fundamental problem with broad
impact in numerous scientific fields. While extensive research has been dedicated to …