BM Leon, TM Maddox - World journal of diabetes, 2015 - ncbi.nlm.nih.gov
The incidence of diabetes mellitus (DM) continues to rise and has quickly become one of the most prevalent and costly chronic diseases worldwide. A close link exists between DM and …
AA Gibb, BG Hill - Circulation research, 2018 - Am Heart Assoc
Metabolic pathways integrate to support tissue homeostasis and to prompt changes in cell phenotype. In particular, the heart consumes relatively large amounts of substrate not only to …
Cardiac hypertrophy can be defined as an increase in heart mass. Pathological cardiac hypertrophy (heart growth that occurs in settings of disease, eg hypertension) is a key risk …
JR Sowers, M Epstein, ED Frohlich - Hypertension, 2001 - Am Heart Assoc
Cardiovascular diseases (CVDs) are the major causes of mortality in persons with diabetes, and many factors, including hypertension, contribute to this high prevalence of CVD …
The heart is a highly structured organ consisting of different cell types, including myocytes, endothelial cells, fibroblasts, stem cells, and inflammatory cells. This pluricellularity provides …
SI McFarlane, M Banerji… - The Journal of Clinical …, 2001 - academic.oup.com
INSULIN RESISTANCE describes an impaired biological response to insulin (1–4). In the early states of insulin resistance there is a compensatory increase in insulin concentrations …
L Elia, R Contu, M Quintavalle, F Varrone, C Chimenti… - Circulation, 2009 - Am Heart Assoc
Background—MicroRNAs (miRNAs/miRs) are small conserved RNA molecules of 22 nucleotides that negatively modulate gene expression primarily through base paring to the …
JR McMullen, T Shioi, WY Huang, L Zhang… - Journal of Biological …, 2004 - ASBMB
Insulin-like growth factor 1 (IGF1) was considered a potential candidate for the treatment of heart failure. However, some animal studies and clinical trials have questioned whether …
We hypothesized that mesenchymal stem cells (MSCs) overexpressing insulin-like growth factor (IGF)-1 showed improved survival and engraftment in the infarcted heart and …