Though totipotency and pluripotency are transient during early embryogenesis, they
establish the foundation for the development of all mammals. Studying these in vivo has …

In vitro stem cell models that replicate human gastrulation have been generated, but they
lack the essential extraembryonic cells needed for embryonic development, morphogenesis …

Despite being the predominant genetic elements in mammalian genomes, retrotransposons
were often dismissed as genomic parasites with ambiguous biological significance …

Implantation of the human embryo begins a critical developmental stage that comprises
profound events including axis formation, gastrulation and the emergence of haematopoietic …

The evolution of embryo models | Nature Methods Skip to main content Thank you for
visiting nature.com. You are using a browser version with limited support for CSS. To obtain …

Why researchers should use human embryo models with caution Skip to main content Thank
you for visiting nature.com. You are using a browser version with limited support for CSS. To …

With the advancement of human stem cell cultures and interest in understanding human
embryogenesis, human blastocyst-like structures, or human blastoids, are being developed …

In contrast to rodents, the mechanisms underlying human trophectoderm and early placenta
specification are understudied due to ethical barriers and the scarcity of embryos. Recent …

Stem cells used to model a two-week-old human embryo Skip to main content Thank you for
visiting nature.com. You are using a browser version with limited support for CSS. To obtain the …

Human naïve pluripotent stem cells (hnPSCs) can generate integrated models of blastocysts
termed blastoids upon switch to inductive medium. However, the underlying mechanisms …