Aim The aim was to investigate associations between drugs with anticholinergic effects
(DACEs) and cognitive impairment, falls and all‐cause mortality in older adults. Methods A …

Organophosphorus pesticide self-poisoning is an important clinical problem in rural regions
of the developing world, and kills an estimated 200 000 people every year. Unintentional …

Scopolamine is used as a standard/reference drug for inducing cognitive deficits in healthy
humans and animals. Effects are often interpreted in terms of a role of acetylcholine in …

PuRPosE: Calotropis gigantea R. Br.(Asclepiadaceae) a wildly growing plant has been
reported to possess number of medicinal properties and other purposes. The purpose of the …

Introduction: Anticholinergics are a class of medicines that block the neurotransmitter,
acetylcholine, in the brain and peripheral tissues. Medicines with anticholinergic activity are …

Abstract The alkaloid L-(−)-scopolamine [L-(−)-hyoscine] competitively inhibits muscarinic
receptors for acetylcholine and acts as a nonselective muscarinic antagonist, producing both …

Based on electrophysiological, neurochemical and neuropharmacological approaches, it is
currently accepted that serotonin (5-HT) and dopamine (DA) function to promote waking (W) …

Large numbers of patients referred for evaluation of chest pain are unable to perform
adequate, diagnostic exercise testing. In these patients, dobutamine stress …

Members of the muscarinic acetylcholine receptor family are thought to play key roles in the
regulation of a large number of important functions of the CNS. However, the precise roles of …

Background Exercise and its recovery period are associated with increased risk of death
relative to sedentary periods. They are also accompanied by dynamic changes in autonomic …