Over the past decade, rapid advances in genomics, proteomics and functional genomics
technologies that enable in-depth interrogation of cancer genomes and proteomes and high …

ROCK belongs to the AGC family of Ser/Thr protein kinases that are involved in many
cellular processes. ROCK-driven actomyosin contractility regulates cytoskeletal dynamics …

Simple Summary Patients with advanced melanoma are often treated with v-raf murine
sarcoma viral oncogene homolog B1 (BRAF) inhibitors. Although these agents prolong life …

Rho-associated kinases 1 and 2 (ROCK1/2) are Rho-GTPase effectors that control key
aspects of the actin cytoskeleton, but their role in proliferation and cancer initiation or …

Most patients with BRAF-mutant metastatic melanoma display remarkable but incomplete
and short-lived responses to inhibitors of the BRAF kinase or the mitogen-activated protein …

Modern proteomics has proven instrumental in our understanding of the molecular
deregulations associated with the development and progression of cancer. Herein, we …

Patients with malignant melanoma have a 5-year survival rate of only 15–20% once the
tumor has metastasized to distant tissues. While MAP kinase pathway inhibitors (MAPKi) are …

Protein phosphorylation is an essential post-translational modification (PTM) regulating
many biological processes at the cellular and multicellular level. Continuous improvements …

Rho‐associated protein kinase (ROCK) plays crucial roles in the proliferation and migration
of different types of cells. ROCK inhibitor Y‐27632 was previously reported to inhibit …

FOX families play important roles in biological processes, including metabolism,
development, differentiation, proliferation, apoptosis, migration, invasion and longevity. Here …