KSHV LANA—the master regulator of KSHV latency

T Uppal, S Banerjee, Z Sun, SC Verma, ES Robertson - Viruses, 2014 - mdpi.com
Kaposi's sarcoma associated herpesvirus (KSHV), like other human herpes viruses,
establishes a biphasic life cycle referred to as dormant or latent, and productive or lytic …

Keeping it quiet: chromatin control of gammaherpesvirus latency

PM Lieberman - Nature reviews Microbiology, 2013 - nature.com
Abstract The human gammaherpesviruses Epstein–Barr virus (EBV) and Kaposi's sarcoma-
associated herpesvirus (KSHV) establish long-term latent infections associated with diverse …

Control of viral latency by episome maintenance proteins

A De Leo, A Calderon, PM Lieberman - Trends in microbiology, 2020 - cell.com
The human DNA tumor viruses Epstein–Barr virus (EBV), Kaposi's sarcoma-associated
herpesvirus (KSHV), and human papillomavirus (HPV) share the common property of …

Towards better understanding of KSHV life cycle: from transcription and posttranscriptional regulations to pathogenesis

L Yan, V Majerciak, ZM Zheng, K Lan - Virologica Sinica, 2019 - Springer
Kaposi's sarcoma-associated herpesvirus (KSHV), also known as human herpesvirus-8
(HHV-8), is etiologically linked to the development of Kaposi's sarcoma, primary effusion …

KSHV genome replication and maintenance

P Purushothaman, P Dabral, N Gupta… - Frontiers in …, 2016 - frontiersin.org
Kaposi's sarcoma associated herpesvirus (KSHV) or human herpesvirus 8 (HHV8) is a
major etiological agent for multiple severe malignancies in immune-compromised patients …

G-quadruplex-interacting compounds alter latent DNA replication and episomal persistence of KSHV

A Madireddy, P Purushothaman… - Nucleic acids …, 2016 - academic.oup.com
Kaposi's sarcoma associated herpesvirus (KSHV) establishes life-long latent infection by
persisting as an extra-chromosomal episome in the infected cells and by maintaining its …

The 3D structure of Kaposi sarcoma herpesvirus LANA C-terminal domain bound to DNA

J Hellert, M Weidner-Glunde… - Proceedings of the …, 2015 - National Acad Sciences
Kaposi sarcoma herpesvirus (KSHV) persists as a latent nuclear episome in dividing host
cells. This episome is tethered to host chromatin to ensure proper segregation during …

H2AX phosphorylation is important for LANA-mediated Kaposi's sarcoma-associated herpesvirus episome persistence

HC Jha, SK Upadhyay, MP AJ, J Lu, Q Cai… - Journal of …, 2013 - Am Soc Microbiol
The DNA damage response (DDR) of host cells is utilized by a number of viruses to
establish and propagate their genomes in the infected cells. We examined the expression of …

Kaposi's sarcoma-associated herpesvirus latency-associated nuclear antigen: replicating and shielding viral DNA during viral persistence

M Weidner-Glunde, G Mariggiò, TF Schulz - Journal of virology, 2017 - Am Soc Microbiol
Kaposi's sarcoma herpesvirus (KSHV) establishes lifelong latency. The viral latency-
associated nuclear antigen (LANA) promotes viral persistence by tethering the viral genome …

Kaposi's sarcoma-associated herpesvirus LANA recruits the DNA polymerase clamp loader to mediate efficient replication and virus persistence

Q Sun, T Tsurimoto, F Juillard, L Li… - Proceedings of the …, 2014 - National Acad Sciences
Kaposi's sarcoma-associated herpesvirus (KSHV) latently infects tumor cells and persists as
a multiple-copy, extrachromosomal, circular episome. To persist, the viral genome must …