Mathematical models of biological systems often have components that vary on different
timescales. This multi-timescale character can lead to problems when doing computer …

Bursting is one of the fundamental rhythms that excitable cells can generate either in
response to incoming stimuli or intrinsically. It has been a topic of intense research in …

In amyotrophic lateral sclerosis (ALS) the large motoneurons that innervate the fast-
contracting muscle fibers (F-type motoneurons) are vulnerable and degenerate in …

Key points Intrinsic hyperexcitability of spinal motoneurones is thought to contribute to
excitotoxicity during amyotrophic lateral sclerosis (ALS), but it has never been demonstrated …

The multiple activities of neurons frequently generate several spiking-bursting variations
observed within the neurological mechanism. We show that a discrete fractional-order …

Since their discovery in the late 19th century our conception of motoneurons has steadily
evolved. Motoneurons share the same general function: they drive the contraction of muscle …

Mixed-mode oscillations (MMOs) are a complex dynamical behavior in which each cycle of
oscillation consists of one or more large amplitude spikes followed by one or more small …

The size principle underlies the orderly recruitment of motor units; however, motoneuron
size is a poor predictor of recruitment amongst functionally defined motoneuron subtypes …

Appropriate scaling of motor output from mouse to humans is essential. The motoneurons
that generate all motor output are, however, very different in rodents compared with humans …

This study focuses on computational and theoretical investigations of neuronal activity
arising in the pre-Bötzinger complex (pre-BötC), a medullary region generating the …