The Mendelian randomization approach is an epidemiological study design incorporating
genetic information into traditional epidemiological studies to infer causality of biomarkers …

Background Plasminogen activator inhibitor type 1 (PAI‐1) plays an essential role in the
fibrinolysis system and thrombosis. Population studies have reported that blood PAI‐1 levels …

Background Biological aging estimators derived from DNA methylation data are heritable
and correlate with morbidity and mortality. Consequently, identification of genetic and …

Age at menarche is a marker of timing of puberty in females. It varies widely between
individuals, is a heritable trait and is associated with risks for obesity, type 2 diabetes …

Venous thromboembolism (VTE) is a significant contributor to morbidity and mortality. To
advance our understanding of the biology contributing to VTE, we conducted a genome …

Background: Venous thromboembolism (VTE) is a life-threatening vascular event with
environmental and genetic determinants. Recent VTE genome-wide association studies …

The serine protease inhibitor clade E member 1 (SERPINE1) is a major inhibitor of tissue
plasminogen activator and urokinase, and has been implicated in the development and …

Background Plasminogen activator inhibitor‐1 (PAI‐1), the main inhibitor of fibrinolysis, is
frequently elevated in obesity and could potentially mediate the risk of venous …

Plasminogen activator inhibitor–1 (PAI-1) has been shown to be a key component of the
senescence-related secretome and a direct mediator of cellular senescence. In murine …

Background Endometriosis is recognized as a complex gynecological disorder that can
cause severe pain and infertility, affecting 6–10% of all reproductive-aged women …