Experimental models to study autism spectrum disorders: hiPSCs, rodents and zebrafish

A Pensado-López, S Veiga-Rúa, Á Carracedo… - Genes, 2020 - mdpi.com
Autism Spectrum Disorders (ASD) affect around 1.5% of the global population, which
manifest alterations in communication and socialization, as well as repetitive behaviors or …

Orexins/Hypocretins: Gatekeepers of Social Interaction and Motivation

S Ouaidat, IM Amaral, DG Monteiro, H Harati… - International Journal of …, 2024 - mdpi.com
Ever since the discovery of the brain's orexin/hypocretin system, most research was directed
toward unveiling its contribution to the normal functioning of individuals. The investigation of …

RRP7A links primary microcephaly to dysfunction of ribosome biogenesis, resorption of primary cilia, and neurogenesis

M Farooq, L Lindbæk, N Krogh, C Doganli… - Nature …, 2020 - nature.com
Primary microcephaly (MCPH) is characterized by reduced brain size and intellectual
disability. The exact pathophysiological mechanism underlying MCPH remains to be …

Oxamyl exerts developmental toxic effects in zebrafish by disrupting the mitochondrial electron transport chain and modulating PI3K/Akt and p38 Mapk signaling

G An, T Hong, H Park, W Lim, G Song - Science of The Total Environment, 2023 - Elsevier
Oxamyl, a carbamate insecticide, is mainly used to control nematodes in the agricultural
field. Although oxamyl is a widely used insecticide that is associated with ecological …

Autism-associated protein kinase D2 regulates embryonic cortical neuron development

K Matsumura, M Baba, K Nagayasu… - Biochemical and …, 2019 - Elsevier
Autism spectrum disorder (ASD) is a heterogeneous neurodevelopmental disorder,
characterized by impaired social interaction, repetitive behavior and restricted interests …

Emergence of Dip2-mediated Specific DAG-based PKC Signalling Axis in Eukaryotes

S Shambhavi, S Mondal, A Chakraborty, N Shukla… - bioRxiv, 2024 - biorxiv.org
Diacylglycerols (DAGs) are used for metabolic purposes and are tightly regulated secondary
lipid messengers in eukaryotes. DAG subspecies with different fatty-acyl chains are …

Protein kinase C beta relieves autism‐like behavior in EN2 knockout mice via upregulation of the FTO/PGC‐1α/UCP1 axis

X Song, Q Hu, X Xu, W Pan - Journal of Biochemical and …, 2023 - Wiley Online Library
Increasing evidence suggests that disruption of neuron activity contributes to the autistic
phenotype. Thus, we aimed in this study to explore the role of protein kinase C beta (PKCβ) …

TAK1-mediated phosphorylation of PLCE1 represses PIP2 hydrolysis to impede esophageal squamous cancer metastasis

Q Ju, W Sheng, M Zhang, J Chen, L Wu, X Liu, W Fang… - bioRxiv, 2024 - biorxiv.org
TAK1 is a serine/threonine protein kinase that is a key regulator in a wide variety of cellular
processes. However, the functions and mechanisms involved in cancer metastasis are still …

Causal association between mTOR-dependent circulating protein levels and autism spectrum disorder: a Mendelian randomization study

J Fu, M Dong, L Chen, C Du, Z Yu, H Wang - 2024 - researchsquare.com
Background Overactivation of the mTOR signaling pathway is a critical mechanism in the
pathogenesis of autism spectrum disorder (ASD). However, the causal relationships …

[PDF][PDF] CARACTERIZACIÓN DE LA ACTIVIDAD BIOLÓGICA IN VIVO DE DOS ÉSTERES DE DAFNANO AISLADOS DE HURA CREPITANS (FAMILIA …

ACG Sandoval - repositorio.upch.edu.pe
CARACTERIZACIÓN DE LA ACTIVIDAD BIOLÓGICA IN VIVO DE DOS ÉSTERES DE DAFNANO
AISLADOS DE HURA CREPITANS (FAMILIA EUPHORBIACEAE Page 1 FACULTAD DE …