Caspase-3 is a widely expressed member of a conserved family of proteins, generally
recognized for their activated proteolytic roles in the execution of apoptosis in cells …

Cancer growth represents a dysregulated imbalance between cell gain and cell loss, where
the rate of proliferating mutant tumour cells exceeds the rate of those that die. Apoptosis, the …

The nanocatalytic activity of nanozymes provides a vision for tumor treatment. However, the
glutathione (GSH)-related antioxidant defense system (ADS) formed on the basis of …

Cell suicide pathways, termed regulated cell death (RCD), play a critical role in organismal
development, homeostasis, and pathogenesis. Here, we provide an overview of key RCD …

Tumor-associated macrophages (TAMs) constitute a plastic and heterogeneous cell
population of the tumor microenvironment (TME) that can account for up to 50% of some …

The resolution of inflammation has emerged as a critical endogenous process that protects
host tissues from prolonged or excessive inflammation that can become chronic. Failure of …

Over the past decade, the Nomenclature Committee on Cell Death (NCCD) has formulated
guidelines for the definition and interpretation of cell death from morphological, biochemical …

Regulated cell death (RCD) is essential for successful systemic cancer therapy. Yet, the
engagement of RCD pathways does not inevitably result in cell death. Instead, RCD …

Ruptured and intact plasma membranes are classically considered as hallmarks of necrotic
and apoptotic cell death, respectively. As such, apoptosis is usually considered a non …

Apoptosis shapes development and differentiation, has a key role in tissue homeostasis,
and is deregulated in cancer. In most cases, successful apoptosis is triggered by …