The fragile X-related disorders are an important group of hereditary disorders that are
caused by expanded CGG repeats in the 5′ untranslated region of the FMR1 gene or by …

Astrocytes have an important role in neuronal maturation and synapse function in the brain.
The interplay between astrocytes and neurons is found to be altered in many …

Background Sepsis is an abnormal immune response after infection, wherein the lung is the
most susceptible organ to fail, leading to acute lung injury. To overcome the limitations of …

Fragile X syndrome (FXS) is a genetic neurodevelopmental disorder characterized by
intellectual disability and is related to autism. FXS is caused by mutations of the fragile X …

Fragile X syndrome (FXS) is caused by the loss of the fragile X messenger ribonucleoprotein
1 (FMRP) encoded by the FMR1 gene. Gene therapy using adeno-associated virus (AAV) to …

Adeno-associated virus (AAV) vectors have emerged as a promising tool in the development
of gene therapies for various neurological diseases, including Alzheimer's disease and …

Fragile X Syndrome (FXS) is a neurological disorder caused by epigenetic silencing of the
FMR1 gene. Reactivation of FMR1 is a potential therapeutic approach for FXS that would …

Lipids are essential components of eukaryotic membranes, playing crucial roles in
membrane structure, energy storage, and signaling. They are predominantly synthesized in …

Fragile X syndrome (FXS) is a neurodevelopmental disorder caused by a full mutation (>
200 CGG repeats) in the FMR1 gene. FXS is the leading cause of inherited intellectual …

Diacylglycerol kinases (DGKs) control local and temporal amounts of diacylglycerol (DAG)
and phosphatidic acid (PA) by converting DAG to PA through phosphorylation in cells …