Oxidative stress is known to play an important role in the pathogenesis of a number of
diseases. In particular, it is linked to the etiology of Alzheimer's disease (AD), an age-related …

Alzheimer's disease (AD) challenges our society with an annual estimated cost of $1.08
trillion in the United States alone by 2050. 1 AD is a progressive irreversible neurological …

Multiple abnormalities occur in the homeostasis of essential endogenous brain biometals in
age-related neurodegenerative disorders, Alzheimer's disease, Parkinson's disease …

Alzheimer's disease (AD) 1− 3 is the most common form of dementia (estimated∼ 50− 60%
of all cases), associated with loss of memory (in particular episodic memory), cognitive …

Progressive cerebral deposition of the amyloid β-protein (Aβ) in brain regions serving
memory and cognition is an invariant and defining feature of Alzheimer disease. A highly …

The basic role of metal ions including copper, zinc and iron in neurological pathologies is
generally accepted. The relationship between the development of disease and particular …

Metal ions, such as copper and zinc ions, have been shown to strongly modulate the self-
assembly of the amyloid-β (Aβ) peptide into insoluble fibrils, and elevated concentrations of …

Copper is a redox-active metal with many important biological roles. Consequently, its
distribution and oxidation state are subject to stringent regulation. A large body of …

Amyloids can have normal biological functions. 1r3 However, amyloidogenic proteins can
also form unwanted oligomeric or polymeric aggregates when disturbed from their native …

Amyloid-β peptides (Aβ) are key molecules in Alzheimer's disease (AD) pathology as they
form amyloid plaques that are primary hallmarks of AD. There is increasing evidence …