Adverse outcome pathways for ionizing radiation and breast cancer involve direct and indirect DNA damage, oxidative stress, inflammation, genomic instability, and …
JS Helm, RA Rudel - Archives of toxicology, 2020 - Springer
Abstract Knowledge about established breast carcinogens can support improved and
modernized toxicological testing methods by identifying key mechanistic events. Ionizing …
modernized toxicological testing methods by identifying key mechanistic events. Ionizing …
Impairment of the non-homologous end joining and homologous recombination pathways of DNA double strand break repair: Impact on spontaneous and radiation …
JW Haines, M Coster, SD Bouffler - DNA repair, 2015 - Elsevier
Female Apc min/+ mice carrying the BALB/c variant of Prkdc or heterozygous knockout for
Xrcc2, were sham-or 2 Gy X-irradiated as adults to compare the effect of mild impairments of …
Xrcc2, were sham-or 2 Gy X-irradiated as adults to compare the effect of mild impairments of …
Xrcc2 Modulates Spontaneous and Radiation-Induced Tumorigenesis in Apcmin/+ Mice
JW Haines, MR Coster, J Adam, M Cheeseman… - Molecular Cancer …, 2010 - AACR
XRCC2 has an important role in repair of DNA damage by homologous recombination. Adult
Apcmin/+(min, multiple intestinal neoplasia) mice, wild-type or heterozygous for Xrcc2 …
Apcmin/+(min, multiple intestinal neoplasia) mice, wild-type or heterozygous for Xrcc2 …
The stromal gene encoding the CD274 antigen as a genetic modifier controlling survival of mice with γ-radiation-induced T-cell lymphoblastic lymphomas
J Santos, L Gonzalez-Sanchez, M Villa-Morales, I Ors… - Oncogene, 2010 - nature.com
Using an inter-specific subcongenic strain, Nested Recombinant Haplotype 3 (NRH3),
generated between two mouse strains showing extreme differences in γ-radiation-induced …
generated between two mouse strains showing extreme differences in γ-radiation-induced …
Genetic control of susceptibility to carcinogen-induced colorectal cancer in mice: The Ccs3 and Ccs5 loci regulate different aspects of tumorigenesis
C Meunier, T Kwan, C Turbide, N Beauchemin, P Gros - Cell Cycle, 2011 - Taylor & Francis
Colorectal cancer (CRC) is a multistep disease that involves a two-way interaction between
a complex genetic pre-disposition component, and a set of poorly understood extrinsic …
a complex genetic pre-disposition component, and a set of poorly understood extrinsic …
A strategy to identify dominant point mutant modifiers of a quantitative trait
WF Dove, A Shedlovsky, L Clipson… - G3: Genes …, 2014 - academic.oup.com
A central goal in the analysis of complex traits is to identify genes that modify a phenotype.
Modifiers of a cancer phenotype may act either intrinsically or extrinsically on the salient cell …
Modifiers of a cancer phenotype may act either intrinsically or extrinsically on the salient cell …
[图书][B] Indentifying genetic determinants of colorectal cancer susceptibility in mice
LA Van Der Kraak - 2014 - search.proquest.com
Inbred mice differ with respect to colitis-associated colorectal cancer (CA-CRC) susceptibility
due to inherited genetic factors. However, little is known with respect to the precise genetic …
due to inherited genetic factors. However, little is known with respect to the precise genetic …