Type II bacterial toxin–antitoxins: hypotheses, facts, and the newfound plethora of the PezAT system

WT Chan, MP Garcillán-Barcia, CC Yeo… - FEMS Microbiology …, 2023 - academic.oup.com
Toxin–antitoxin (TA) systems are entities found in the prokaryotic genomes, with eight
reported types. Type II, the best characterized, is comprised of two genes organized as an …

[HTML][HTML] The Toxin of VapBC-1 Toxin-Antitoxin Module from Leptospira interrogans Is a Ribonuclease That Does Not Arrest Bacterial Growth but Affects Cell Viability

DK Damiano, BOP Azevedo, GSC Fernandes… - Microorganisms, 2024 - mdpi.com
Bacterial ubiquitous Toxin-Antitoxin (TA) systems are considered to be important survival
mechanisms during stress conditions. In regular environmental conditions, the antitoxin …

Structural and Functional Analyses of STM14_5441-STM14_5442: A Potential Mechanism for Persister Formation Against Aminoglycosides

HJ Eun, SW Jang, JH Park, J Lee, KY Lee, EJ Lee… - Drug Resistance …, 2025 - Elsevier
Aims The ability to eliminate bacterial persister cells is still a medical challenge that has yet
to be overcome. These cells represent a unique subpopulation within bacterial communities …

[HTML][HTML] Toxin-antitoxin systems reflect community interactions through horizontal gene transfer

JH Bethke, J Kimbrel, Y Jiao… - Molecular Biology and …, 2024 - pmc.ncbi.nlm.nih.gov
Bacterial evolution through horizontal gene transfer (HGT) reflects their community
interactions. In this way, HGT networks do well at mapping community interactions, but offer …

Toxin-antitoxin genes are differentially expressed in Escherichia coli relA and spoT mutans cultured under nitrogen, fatty acid, or carbon starvation conditions

M Maciąg-Dorszyńska, P Olszewski… - Frontiers in …, 2025 - frontiersin.org
Introduction The stringent response is one of the fundamental mechanisms that control and
modulate bacterial adaptation to stress conditions, such as nutrient limitation. The …

[HTML][HTML] Use of Bacterial Toxin–Antitoxin Systems as Biotechnological Tools in Plants

B Rodamilans, X Cheng… - … Journal of Molecular …, 2024 - pmc.ncbi.nlm.nih.gov
Toxin–antitoxin (TA) systems in bacteria are key regulators of the cell cycle and can activate
a death response under stress conditions. Like other bacterial elements, TA modules have …

Distribution of lineages and type II toxin-antitoxin systems among rifampin-resistant Mycobacterium Tuberculosis Isolates

M Shafipour, A Mohammadzadeh, P Mahmoodi… - Plos one, 2024 - journals.plos.org
Type II toxin-antitoxin systems such as mazEF3, vapBC3, and relJK play a role in antibiotic
resistance and tolerance. Among the different known TA systems, mazEF3, vapBC3, and …

PCR Development for Analysis of Some Type II Toxin–Antitoxin Systems, relJK, mazEF3, and vapBC3 Genes, in Mycobacterium tuberculosis and Mycobacterium …

M Shafipour, A Mohammadzadeh, EA Ghaemi… - Current …, 2024 - Springer
Toxin–Antitoxin (TA) systems are some small genetic modules in bacteria that play
significant roles in resistance and tolerance development to antibiotics. Whole genome …

[PDF][PDF] Targeted Therapy for Intracellular Bacterial Pathogens

C Ghazaei - International Journal of Basic Sciences in Medicine, 2024 - sid.ir
The spectrum of diseases caused by intracellular bacterial pathogens (IBPs) is broad,
ranging from life-threatening conditions such as tuberculosis to other infectious-transmitted …

Exploring Transduction and Adaptation of Plasmids in Antimicrobial Resistance

EF Wedel - 2024 - docta.ucm.es
Exploring Transduction and Adaptation of Plasmids in Antimicrobial Resistance Page 1
UNIVERSIDAD COMPLUTENSE DE MADRID FACULTAD DE VETERINARIA TESIS DOCTORAL …