Sickle cell disease (SCD) predominates in sub‐Saharan Africa, East Mediterranean areas,
Middle East, and India. Nigeria, being the most populous black nation in the world, bears its …

Introduction: sickle cell disease (SCD) is a hereditary red blood cell disorder of public health
importance globally with Nigeria the epicenter zone in Africa. There is a paucity of …

Background: Sickle cell disease (SCD) is a major public health problem in Nigeria. Carrier
prevalence is about 25% and it affects about 2–3% of the Nigerian population. The disease …

Evidence suggests that impairment in caregiver wellbeing can alter the quality of care in
children with sickle cell disease. We examined 121 parent caregivers of adolescents with …

The huge burden of sickle cell disease (SCD) coupled with a correspondingly high morbidity
and mortality, particularly in Sub-Saharan Africa, has made it really imperative to invest more …

Sickle cell disease is an autosomal recessive disorder of the beta-globin gene, with resultant
deformation of the red blood cells and variable clinical outcomes. Nigeria is recognised as …

Iron is an essential element and the most abundant trace metal in the body involved in
oxygen transport and oxygen sensing, electron transfer, energy metabolism, and DNA …

Background: Sickle cell anaemia is an autosomal recessive disorder which occurs as a
result of the substitution of glutamic acid with valine at the 6 th position of the haemoglobin …

Introduction: sickle cell disease and HIV infection are prevalent in sub-Saharan Africa. While
Haemoglobin S (HbS) contributes to significant morbidity and mortality in the homozygous or …

Background: The clinical prospects of hydroxyurea therapy in the management of sickle cell
disease (SCD) require evaluation in the Nigerian setting to develop indigenous guidelines …