A fundamental goal of developmental and stem cell biology is to map the developmental
history (ontogeny) of differentiated cell types. Recent advances in high-throughput single …

The development of mature blood cells from haematopoietic stem cells has long served as a
model for stem-cell research, with the haematopoietic differentiation tree being widely used …

Haematopoietic stem cells drive blood production, but their population size and lifetime
dynamics have not been quantified directly in humans. Here we identified 129,582 …

Haematopoietic stem cells (HSCs) are widely studied by HSC transplantation into immune-
and blood-cell-depleted recipients. Single HSCs can rebuild the system after …

It is currently thought that life-long blood cell production is driven by the action of a small
number of multipotent haematopoietic stem cells. Evidence supporting this view has been …

Hematopoiesis has long served as a paradigm of stem cell biology and tissue homeostasis.
In the past decade, the genomics revolution has ushered in powerful new methods for …

The self-renewal capacity of multipotent haematopoietic stem cells (HSCs) supports blood
system homeostasis throughout life and underlies the curative capacity of clinical HSC …

Transplantation of hematopoietic stem cells (HSCs) from human umbilical cord blood
(hUCB) holds great promise for treating a broad spectrum of hematological disorders …

Intratumoral heterogeneity arises through the evolution of genetically diverse subclones
during tumor progression. However, it remains unknown whether cells within single genetic …

Lineage tracing is the identification of all progeny of a single cell. Although its origins date
back to developmental biology of invertebrates in the 19 th century, lineage tracing is now …