RNA-binding proteins (RBPs) are central to most if not all cellular processes, dictating the
fate of virtually all RNA molecules in the cell. Starting with pioneering work on ribosomal …

Multi-subunit DNA-dependent RNA polymerases synthesize all classes of cellular RNAs,
ranging from short regulatory transcripts to gigantic messenger RNAs. RNA polymerase has …

INTRODUCTION Factor-dependent transcription termination is essential to limit pervasive
transcription, maintain genome stability, balance the expression of neighboring genes, and …

Transcription termination is an essential step in transcription by RNA polymerase (RNAP)
and crucial for gene regulation. For many bacterial genes, transcription termination is …

Rho is a general transcription termination factor playing essential roles in RNA polymerase
(RNAP) recycling, gene regulation, and genomic stability in most bacteria. Traditional …

Summary NusG/RfaH/Spt5 transcription elongation factors are the only transcription
regulators conserved across all life. Bacterial NusG regulates RNA polymerase (RNAP) …

Transcriptional pausing by RNA polymerases (RNAPs) is a key mechanism to regulate gene
expression in all kingdoms of life and is a prerequisite for transcription termination. The …

Protein-protein interactions govern most cellular pathways and processes, and multiple
technologies have emerged to systematically map them. Assessing the error of interaction …

RNA polymerase (RNAP) frequently pauses during the transcription of DNA to RNA to
regulate gene expression. Transcription factors NusA and NusG modulate pausing, have …

Bacteriophage λN protein, a model anti-termination factor, binds nascent RNA and host Nus
factors, rendering RNA polymerase resistant to all pause and termination signals. A 3.7-Å …