Revisiting biomarker discovery by plasma proteomics

PE Geyer, LM Holdt, D Teupser… - Molecular systems biology, 2017 - embopress.org
Clinical analysis of blood is the most widespread diagnostic procedure in medicine, and
blood biomarkers are used to categorize patients and to support treatment decisions …

SWATH‐MS as a tool for biomarker discovery: From basic research to clinical applications

SI Anjo, C Santa, B Manadas - Proteomics, 2017 - Wiley Online Library
In the era of quantitative proteomics, where mass spectrometry plays a pivotal role, in
particular associated with the use of data‐independent acquisition, it is time to perform an …

[HTML][HTML] Seasonal shift of the gut microbiome synchronizes host peripheral circadian rhythm for physiological adaptation to a low-fat diet in the giant panda

G Huang, L Wang, J Li, R Hou, M Wang, Z Wang, Q Qu… - Cell Reports, 2022 - cell.com
Characteristics of the gut microbiome vary synchronously with changes in host diet.
However, the underlying effects of these fluctuations remain unclear. Here, we performed …

Proteomics reveals the effects of sustained weight loss on the human plasma proteome

PE Geyer, NJ Wewer Albrechtsen… - Molecular systems …, 2016 - embopress.org
Sustained weight loss is a preferred intervention in a wide range of metabolic conditions, but
the effects on an individual's health state remain ill‐defined. Here, we investigate the plasma …

Reproducibility, specificity and accuracy of relative quantification using spectral library-based data-independent acquisition

K Barkovits, S Pacharra, K Pfeiffer, S Steinbach… - Molecular & Cellular …, 2020 - ASBMB
Currently data-dependent acquisition (DDA) is the method of choice for mass spectrometry-
based proteomics discovery experiments, but data-independent acquisition (DIA) is steadily …

Mistimed food intake and sleep alters 24-hour time-of-day patterns of the human plasma proteome

CM Depner, EL Melanson… - Proceedings of the …, 2018 - National Acad Sciences
Proteomics holds great promise for understanding human physiology, developing health
biomarkers, and precision medicine. However, how much the plasma proteome varies with …

Proteomic analysis of human plasma during intermittent fasting

DJ Harney, AT Hutchison, L Hatchwell… - Journal of proteome …, 2019 - ACS Publications
Intermittent fasting (IF) increases lifespan and decreases metabolic disease phenotypes and
cancer risk in model organisms, but the health benefits of IF in humans are less clear …

Mass spectrometry for the discovery of biomarkers of sepsis

KR Ludwig, AB Hummon - Molecular BioSystems, 2017 - pubs.rsc.org
Sepsis is a serious medical condition that occurs in 30% of patients in intensive care units
(ICUs). Early detection of sepsis is key to prevent its progression to severe sepsis and septic …

Evaluation of the molecular mechanisms of sepsis using proteomics

H Miao, S Chen, R Ding - Frontiers in Immunology, 2021 - frontiersin.org
Sepsis is a complex syndrome promoted by pathogenic and host factors; it is characterized
by dysregulated host responses and multiple organ dysfunction, which can lead to death …

Proteomic atlas of organ vasculopathies triggered by Staphylococcus aureus sepsis

AG Toledo, G Golden, AR Campos, H Cuello… - Nature …, 2019 - nature.com
Sepsis is a life-threatening condition triggered by a dysregulated host response to microbial
infection resulting in vascular dysfunction, organ failure and death. Here we provide a semi …