Since the original identification of the T helper 17 (Th17) subset in 2005, it has become
evident that these cells do not only contribute to host defence against pathogens, such as …

Abstract The T helper 17 (Th17) cells contain a dynamic subset of CD4+ T-cells that are able
to develop into other different lineage subsets, including the Th1-like Th17 cells. These cells …

FOXO1 transcription factors affect a number of cell types that are important in the host
response. Cell types whose functions are modulated by FOXO1 include keratinocytes in the …

β2 integrins are heterodimeric surface receptors composed of a variable α (CD11a-CD11d)
and a constant β (CD18) subunit and are specifically expressed by leukocytes. The α …

Background The relationship between pancreatic cancer (PC) and type 2 diabetes mellitus
(T2DM) has long been widely recognized, but the interaction mechanisms are still unknown …

Objectives Although T cells have been implicated in the pathogenesis of systemic sclerosis
(SSc), a comprehensive study of T-cell-mediated immune responses in the affected skin of …

IgA nephropathy (IgAN) is the most prevalent primary glomerulonephritis worldwide, with
diverse clinical manifestations characterized by recurrent gross hematuria or microscopic …

T follicular helper (Tfh) cells play key role in providing help to B cells during germinal center
(GC) reactions. Generation of protective antibodies against various infections is an important …

Autoimmune thyroid diseases (AITD) are a group of both B cell-and T cell-mediated organ-
specific autoimmune diseases. Graves' disease and Hashimoto thyroiditis are the two main …

Abstract Interleukin (IL)-6 is produced locally in response to an inflammatory stimulus, and is
able to induce systemic manifestations at distance from the site of inflammation. Its unique …