Immunogenic cell death inducing metal complexes for cancer therapy

L Zhang, N Montesdeoca, J Karges… - Angewandte Chemie …, 2023 - Wiley Online Library
Cancer is one of the deadliest diseases worldwide. Recent statistics have shown that
metastases and tumor relapse are the leading causes of cancer‐associated deaths. While …

Metal-based anticancer agents as immunogenic cell death inducers: the past, present, and future

S Sen, M Won, MS Levine, Y Noh… - Chemical Society …, 2022 - pubs.rsc.org
Cancer is the deadliest disease in the world behind heart disease. Sadly, this remains true
even as we suffer the ravages of the Covid-19 pandemic. Whilst current chemo-and …

Visible-to-NIR-light activated release: from small molecules to nanomaterials

R Weinstain, T Slanina, D Kand, P Klan - Chemical reviews, 2020 - ACS Publications
Photoactivatable (alternatively, photoremovable, photoreleasable, or photocleavable)
protecting groups (PPGs), also known as caged or photocaged compounds, are used to …

Stimuli-responsive polymer-based nanosystems for cancer theranostics

D Wei, Y Sun, H Zhu, Q Fu - ACS nano, 2023 - ACS Publications
Stimuli-responsive polymers can respond to internal stimuli, such as reactive oxygen
species (ROS), glutathione (GSH), and pH, biological stimuli, such as enzymes, and external …

In response to precision medicine: Current subcellular targeting strategies for cancer therapy

Z Li, J Zou, X Chen - Advanced Materials, 2023 - Wiley Online Library
Emerging as a potent anticancer treatment, subcellular targeted cancer therapy has drawn
increasing attention, bringing great opportunities for clinical application. Here, two targeting …

A carbonic anhydrase IX (CAIX)‐anchored rhenium (I) photosensitizer evokes pyroptosis for enhanced anti‐tumor immunity

X Su, WJ Wang, Q Cao, H Zhang, B Liu… - Angewandte Chemie …, 2022 - Wiley Online Library
An ideal cancer treatment should not only destroy primary tumors but also improve the
immunogenicity of the tumor microenvironment to achieve a satisfactory anti‐tumor immune …

Photo‐Reduction with NIR Light of Nucleus‐Targeting PtIV Nanoparticles for Combined Tumor‐Targeted Chemotherapy and Photodynamic Immunotherapy

D Wei, Y Huang, B Wang, L Ma… - Angewandte Chemie …, 2022 - Wiley Online Library
The development of PtIV prodrugs which are selectively reduced within cancerous cells into
their PtII therapeutically active species has received increasing attention within the last …

Near-infrared-activated anticancer platinum (IV) complexes directly photooxidize biomolecules in an oxygen-independent manner

Z Deng, H Li, S Chen, N Wang, G Liu, D Liu, W Ou… - Nature Chemistry, 2023 - nature.com
Conventional light-driven cancer therapeutics require oxygen and visible light to indirectly
damage biomolecules, limiting their efficacy in deep, hypoxic tumours. Here we report the …

Emerging strategies in stimuli-responsive prodrug nanosystems for cancer therapy

C Ding, C Chen, X Zeng, H Chen, Y Zhao - ACS nano, 2022 - ACS Publications
Prodrugs are chemically modified drug molecules that are inactive before administration.
After administration, they are converted in situ to parent drugs and induce the mechanism of …

Functional nucleic acids-engineered bio-barcode nanoplatforms for targeted synergistic therapy of multidrug-resistant cancer

S Zhi, X Zhang, J Zhang, X Wang, S Bi - ACS nano, 2023 - ACS Publications
Rational design of multifunctional nanomedicines has revolutionized the therapeutic efficacy
of cancers. Herein, we have constructed the functional nucleic acids (FNAs)-engineered …