Background Substantial amounts of public funds are invested in health research worldwide.
Publicly funded randomised controlled trials (RCTs) often recruit participants at a slower …

Background A commonly reported problem with the conduct of multicentre randomised
controlled trials (RCTs) is that recruitment is often slower or more difficult than expected, with …

This report presents the Consolidated Standards of Reporting Trials (CONSORT) extension
for the stepped wedge cluster randomised trial (SW-CRT). The SW-CRT involves …

The Consolidated Standards of Reporting Trials (CONSORT) statement was developed to
improve the reporting of randomised controlled trials. It was initially published in 1996 and …

Randomised controlled trials are widely accepted as the most reliable method of
determining effectiveness, but most trials have evaluated the effects of a single intervention …

The resurgence of interest in the effect of neighborhood contexts on health outcomes,
motivated by advances in social epidemiology, multilevel theories and sophisticated …

Background Neonatal deaths in developing countries make the largest contribution to global
mortality in children younger than 5 years. 90% of deliveries in the poorest quintile of …

Objectives: To identify factors associated with good and poor recruitment to multicentre trials.
Data sources: Part A: database of trials started in or after 1994 and were due to end before …

It is now well known that standard statistical procedures become invalidated when applied to
cluster randomized trials in which the unit of inference is the individual. A resulting …

The Ottawa Statement on the Ethical Design and Conduct of Cluster Randomized Trials | PLOS
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