Bacterial infections caused by 'superbugs' are increasing globally, and conventional
antibiotics are becoming less effective against these bacteria, such that we risk entering a …

The management of bacterial infections is becoming a major clinical challenge due to the
rapid evolution of antibiotic resistant bacteria. As an excellent candidate to overcome …

Defensins are a family of cationic antimicrobial peptides active against a broad range of
infectious microbes including bacteria, viruses and fungi, playing important roles as innate …

Defensins are a major family of host defense peptides expressed predominantly in
neutrophils and epithelial cells. Their broad antimicrobial activities and multifaceted …

As a family of cationic host defense peptides, defensins are mainly synthesized by Paneth
cells, neutrophils, and epithelial cells, contributing to host defense. Their biological functions …

Shigella spp. are diarrheal pathogens closely related to Escherichia coli. They are named
after Kiyoshi Shiga, who in 1898 identified its most virulent member, Shigella dysenteriae, as …

Antibiotics with multiple mechanisms of action and broad-spectrum are urgently required to
combat the growing health threat posed by resistant pathogenic microorganisms. Combining …

Shigella is a major global pathogen and the etiological agent of shigellosis, a diarrheal
disease that primarily affects low-and middle-income countries. Shigellosis is characterized …

The enteric bacterium and intracellular human pathogen Shigella causes hundreds of
millions of cases of the diarrheal disease shigellosis per year worldwide. Shigella is …

The intestinal tract is the shared locus of intestinal epithelial cells, immune cells, nutrient
digestion and absorption, and microbial survival. The gut in animals faces continuous …