Exciting progress has recently been made in understanding the replication of hepatitis C
virus, a major cause of chronic hepatitis, liver cirrhosis and hepatocellular carcinoma …

Since the discovery of the hepatitis C virus over 15 years ago, scientists have raced to
develop diagnostics, study the virus and find new therapies. Yet virtually every attempt to …

Hepatitis C virus (HCV) is a human pathogen affecting nearly 3% of the world's population.
Chronic infections can lead to cirrhosis and liver cancer. The RNA replication machine of …

C. Proteolytic Processing of Structural Proteins D. Proteolytic Processing of Nonstructural
Proteins E. Cis-Acting RNA Sequences Required for Replication F. Mechanism of RNA …

The urgent need for efficacious drugs to treat chronic hepatitis C virus (HCV) infection
requires a concerted effort to develop inhibitors specific for virally encoded enzymes. We …

Negative-strand RNA viruses represent a significant class of important pathogens that cause
substantial morbidity and mortality in human and animal hosts worldwide. A defining feature …

Disease‐causing microorganisms not only breach anatomical barriers and invade tissues
but also frequently enter host cells, nutrient‐enriched environments amenable to support …

Genetic recombination in positive-strand RNA viruses is a significant evolutionary
mechanism that drives the creation of viral diversity by the formation of novel chimaeric …

The influenza A viruses genome comprises eight single-stranded RNA segments of negative
polarity. Each one is included in a ribonucleoprotein particle (vRNP) containing the …

Although there is strong evidence that hepatitis C virus (HCV) is one of the leading causes of
hepatocellular carcinoma (HCC), there is still much to understand regarding the mechanism …