For many years, transcription factor Sp1 was viewed as a basal transcription factor and
relegated to a role in the regulation of so‐called housekeeping genes. Identification of Sp1's …

The Sp/KLF family contains at least twenty identi® ed members which include Sp1-4 and
numerous kruÈppel-like factors. Members of the family bind with varying af® nities to …

Cells are organized on length scales ranging from ångström to micrometres. However, the
mechanisms by which ångström-scale molecular properties are translated to micrometre …

IN THE LATE 1980s and early 1990s, the elucidation of the molecular basis of acute
promyelocytic leukemia (APL) emerged as a paradigm for the connection between the …

PML is a component of a multiprotein complex, termed nuclear bodies, and the PML protein
was originally discovered in patients suffering from acute promyelocytic leukaemia (APL) …

The PML gene encodes a tumour suppressor protein associated with a distinct subnuclear
domain, the nuclear body. Various functions have been attributed to the PML nuclear body …

The Wnt-responsive transcription factor LEF1 can activate transcription in association with β-
catenin and repress transcription in association with Groucho. In search of additional …

Estrogen receptor-α (ERα) is a ligand-activated transcription factor and a member of the
nuclear receptor superfamily. The classic mechanism of (ERα) action is associated with …

The initiation of transcription is accomplished via interactions of many different proteins with
common and gene-specific regulatory motifs. Clearly, sequence-specific transcription factors …

The epidermal growth factor receptor (ErbB1 or EGFR) has been found to be altered in a
variety of human cancers. A number of agents targeting these receptors, including specific …