The organic cation transporters (OCTs) OCT1, OCT2, OCT3, novel OCT (OCTN) 1, OCTN2,
multidrug and toxin exclusion (MATE) 1, and MATE kidney-specific 2 are polyspecific …

This white paper provides updated International Transporter Consortium (ITC)
recommendations on transporters that are important in drug development following the 3rd …

Drug transporters can govern the absorption, distribution, metabolism, and excretion of
substrate drugs and endogenous substances. Investigations to examine their potential …

Metformin is the most widely prescribed medication for the treatment of type 2 diabetes
(T2D). However, gastrointestinal (GI) side effects develop in~ 25% of patients treated with …

Drug transporters are now widely acknowledged as important determinants governing drug
absorption, excretion, and, in many cases, extent of drug entry into target organs. There is …

The human solute carrier (SLC) superfamily of transporters is comprised of over 400
membrane-bound proteins, and plays essential roles in a multitude of physiological and …

We investigated whether morphine and its pro-drug codeine are substrates of the highly
genetically polymorphic organic cation transporter OCT1 and whether OCT1 polymorphisms …

Drug transporters play an essential role in disposition and effects of multiple drugs. Plasma
concentrations of the victim drug can be modified by drug–drug interactions occurring in …

Advances in genomic technologies have led to a wealth of information identifying genetic
polymorphisms in membrane transporters, specifically how these polymorphisms affect drug …

Protein expression of major hepatic uptake and efflux drug transporters in human pediatric
(n= 69) and adult (n= 41) livers was quantified by liquid chromatography/tandem mass …