L-selectin (CD62L) is a type-I transmembrane glycoprotein and cell adhesion molecule that
is expressed on most circulating leukocytes. Since its identification in 1983, L-selectin has …

Reactive oxygen species (ROS) are key signaling molecules that play an important role in
the progression of inflammatory disorders. An enhanced ROS generation by …

The generation of reactive oxygen species (ROS) plays an important role for the
maintenance of cellular processes and functions in the body. However, the excessive …

One of the major therapeutic goals of modern cardiology is to design strategies aimed at
minimizing myocardial necrosis and optimizing cardiac repair following myocardial …

The burgeoning field of leukocyte trafficking has created new and exciting opportunities in
the clinic. Trafficking signals are being defined that finely control the movement of distinct …

One early phase of atherosclerosis involves the recruitment of inflammatory cells from the
circulation and their transendothelial migration. This process is predominantly mediated by …

Rationale: Neutrophil extracellular trap (NET) formation promotes vascular damage,
thrombosis, and activation of interferon-α–producing plasmacytoid dendritic cells in …

Selectins are carbohydrate-binding molecules that bind to fucosylated and sialylated
glycoprotein ligands, and are found on endothelial cells, leukocytes and platelets. They are …

Myocardial infarction is the most common cause of cardiac injury and results in acute loss of
a large number of myocardial cells. Because the heart has negligible regenerative capacity …

The bone marrow is the site of neutrophil production, a process that is regulated by the
cytokine granulocyte colony‐stimulating factor (G‐CSF). Mature neutrophils are continually …