Safe and effective gene therapy approaches require targeted tissue-specific transfer of a
therapeutic transgene. Besides traditional approaches, such as transcriptional and …

Abstract Concepts and experimental models derived from basic research have been
successfully applied to the field of molecular oncology, tremendously increasing our …

Mesoangioblasts are stem/progenitor cells derived from a subset of pericytes found in
muscle that express alkaline phosphatase. They have been shown to ameliorate the …

CCAAT/enhancer binding protein-α (C/EBPα) induces transdifferentiation of B cells into
macrophages at high efficiencies and enhances reprogramming into induced pluripotent …

Although many techniques can be used to generate multitype-induced pluripotent stem (iPS)
cells from multitype seed cells, improving the efficiency and shortening the period of cell …

Induced pluripotent stem (iPS) cells can differentiate into nearly all types of cells. In contrast
to embryonic stem cells, iPS cells are not subject to immune rejection because they are …

Transplantation therapies aimed at repairing neurodegenerative and neuropathological
conditions of the central nervous system (CNS) have utilized and tested a variety of cell …

During development, cell state transitions are coordinated through changes in the identity of
molecular regulators in a cell type‐and dose‐specific manner. The ability to rationally …

Aims New sources of insulin-secreting cells are strongly required for the cure of diabetes.
Recent successes in differentiating embryonic stem cells, in combination with the discovery …

It is now well-established that somatic cells can be reprogrammed to alternative cell fates by
ectopic coexpression of defined factors. Reprogramming technology has uncovered a huge …