Acute ischemic stroke is a common cause of morbidity and mortality worldwide.
Thrombolysis with recombinant tissue plasminogen activator and endovascular …

The voltage-dependent anion channel 1 (VDAC1) protein, is an important regulator of
mitochondrial function, and serves as a mitochondrial gatekeeper, with responsibility for …

Nitric oxide (NO) is a short-lived, ubiquitous signaling molecule that affects numerous critical
functions in the body. There are markedly conflicting findings in the literature regarding the …

It has long been recognized that energy metabolism is linked to the production of reactive
oxygen species (ROS) and critical enzymes allied to metabolic pathways can be affected by …

Nitric oxide (NO) is a free radical acting as a cellular signaling molecule in many different
biochemical processes. NO is synthesized from l-arginine through the action of the nitric …

Cardiovascular disease affects approximately 60% of the adult population over the age of 65
and represents the number one cause of death in the United States. Coronary …

Patients requiring prolonged intensive care are at high risk for multiple organ failure and
death. Insulin resistance and hyperglycemia accompany critical illness, and the severity of …

This review highlights the important role of redox signaling between mitochondria and
NADPH oxidases. Besides the definition and general importance of redox signaling, the …

Mitochondria produce nitric oxide (NO) through a Ca 2+-sensitive mitochondrial NO
synthase (mtNOS). The NO produced by mtNOS regulates mitochondrial oxygen …

Background—Several clinical studies have demonstrated that levels of adiponectin are
significantly reduced in patients with type 2 diabetes and that adiponectin levels are …