Homeostasis in healthy tissues strongly relies on cell-to-cell adhesion and cell-to-
extracellular matrix interactions. For instance, normal epithelial cells maintain tissue …

Integrins are vital surface adhesion receptors that mediate interactions between the
extracellular matrix (ECM) and cells and are essential for cell migration and the …

Cells reside in a protein network, the extracellular matrix (ECM), which they secrete and
mold into the intercellular space. The ECM exerts profound control over cells. The effects of …

During progression from tumour growth to metastasis, specific integrin signals enable
cancer cells to detach from neighbouring cells, re-orientate their polarity during migration …

▪ Abstract The phosphoinositide 3-kinase (PI3K) family of enzymes is recruited upon growth
factor receptor activation and produces 3′ phosphoinositide lipids. The lipid products of …

Integrins are the adhesion molecules and transmembrane receptors that consist of α and β
subunits. After binding to extracellular matrix components, integrins trigger intracellular …

Integrin receptor binding to extracellular matrix proteins generates intracellular signals via
enhanced tyrosine phosphorylation events that are important for cell growth, survival, and …

Tumor cells can evade chemotherapy by acquiring resistance to apoptosis. We investigated
the molecular mechanism whereby malignant and nonmalignant mammary epithelial cells …

Cell adhesion is critical for the genesis and maintenance of both three-dimensional structure
and normal function in tissues. The biochemical entities mediating cell adhesion are …

The attachment of cells to the extracellular matrix is of crucial importance in the maintenance
of tissue structure and integrity. In stratified epithelia such as in skin as well as in other …