Gestational hypoxia and developmental plasticity
Hypoxia is one of the most common and severe challenges to the maintenance of
homeostasis. Oxygen sensing is a property of all tissues, and the response to hypoxia is …
homeostasis. Oxygen sensing is a property of all tissues, and the response to hypoxia is …
[HTML][HTML] Targeting oncomiRNAs and mimicking tumor suppressor miRNAs: Νew trends in the development of miRNA therapeutic strategies in oncology
R Gambari, E Brognara… - … journal of oncology, 2016 - spandidos-publications.com
MicroRNA (miRNA or miR) therapeutics in cancer are based on targeting or mimicking
miRNAs involved in cancer onset, progression, angiogenesis, epithelial-mesenchymal …
miRNAs involved in cancer onset, progression, angiogenesis, epithelial-mesenchymal …
Combined delivery of temozolomide and anti‐miR221 PNA using mesoporous silica nanoparticles induces apoptosis in resistant glioma cells
Mesoporous silica nanoparticles (MSNPs), 100 nm in size, incorporating a Cy5 fluorophore
within the silica framework, are synthesized and loaded with the anti‐cancer drug …
within the silica framework, are synthesized and loaded with the anti‐cancer drug …
[HTML][HTML] From microRNA functions to microRNA therapeutics: novel targets and novel drugs in breast cancer research and treatment
R Piva, DA Spandidos… - … journal of oncology, 2013 - spandidos-publications.com
MicroRNAs (miRNAs or miRs) are a family of small non‑coding RNAs that regulate gene
expression by the sequence-selective targeting of mRNAs, leading to translational …
expression by the sequence-selective targeting of mRNAs, leading to translational …
[HTML][HTML] Focus: genome editing: therapeutic peptide nucleic acids: principles, limitations, and opportunities
Since their invention in 1991, peptide nucleic acids (PNAs) have been used in a myriad of
chemical and biological assays. More recently, peptide nucleic acids have also been …
chemical and biological assays. More recently, peptide nucleic acids have also been …
miR-210: fine-tuning the hypoxic response
M Ivan, X Huang - … and Cellular Stress: Signaling, Metabolism, Imaging …, 2014 - Springer
Hypoxia is a central component of the tumor microenvironment and represents a major
source of therapeutic failure in cancer therapy. Recent work has provided a wealth of …
source of therapeutic failure in cancer therapy. Recent work has provided a wealth of …
Unlocking the potential of chemically modified peptide nucleic acids for RNA-based therapeutics
RNA therapeutics have emerged as next-generation therapy for the treatment of many
diseases. Unlike small molecules, RNA targeted drugs are not limited by the availability of …
diseases. Unlike small molecules, RNA targeted drugs are not limited by the availability of …
MicroRNAs and long non-coding RNAs in genetic diseases
Since the discovery and classification of non-coding RNAs, their roles have gained great
attention. In this respect, microRNAs and long non-coding RNAs have been firmly …
attention. In this respect, microRNAs and long non-coding RNAs have been firmly …
miR-210 hypoxamiR in Angiogenesis and Diabetes
G Zaccagnini, S Greco, C Voellenkle… - Antioxidants & Redox …, 2022 - liebertpub.com
Significance: microRNA-210 (miR-210) is the master hypoxia-inducible miRNA (hypoxamiR)
since it has been found to be significantly upregulated under hypoxia in a wide range of cell …
since it has been found to be significantly upregulated under hypoxia in a wide range of cell …
Covalent strategies for targeting messenger and non-coding RNAs: an updated review on siRNA, miRNA and antimiR conjugates
S Grijalvo, A Alagia, AF Jorge, R Eritja - Genes, 2018 - mdpi.com
Oligonucleotide-based therapy has become an alternative to classical approaches in the
search of novel therapeutics involving gene-related diseases. Several mechanisms have …
search of novel therapeutics involving gene-related diseases. Several mechanisms have …