[HTML][HTML] From the “One-Molecule, One-Target, One-Disease” Concept towards Looking for Multi-Target Therapeutics for Treating Non-Polio Enterovirus (NPEV) …

H Roux, F Touret, P Rathelot, P Vanelle… - …, 2024 - pmc.ncbi.nlm.nih.gov
Non-polio enteroviruses (NPEVs), namely coxsackieviruses (CV), echoviruses (E),
enteroviruses (EV), and rhinoviruses (RV), are responsible for a wide variety of illnesses …

Boosting the Beat: A Critical Showdown of Levosimendan and Milrinone in Surgical and Non-Surgical Scenarios: A Narrative Review

A Quintero-Altare, C Flórez-Navas… - Journal of …, 2024 - journals.sagepub.com
Acute heart failure, advanced cardiac failure, cardiac surgery, and sepsis are conditions that
require simultaneous treatment to stimulate contractility and/or reduce systemic vascular …

Synergistic effect of roflumilast with dexamethasone in a neutrophilic asthma mouse model

CK Park, TJ An, JH Kim, CK Rhee… - Clinical and …, 2022 - Wiley Online Library
Asthma is a chronic airway inflammatory disease with heterogeneous features. Most cases
of asthma are steroid sensitive, but 5%‐10% are unresponsive to steroids, leading to …

PDE3 inhibition reduces epithelial mast cell numbers in allergic airway inflammation and attenuates degranulation of basophils and mast cells

J Beute, K Ganesh, H Nastiti, R Hoogenboom… - Frontiers in …, 2020 - frontiersin.org
Epithelial mast cells are generally present in the airways of patients with allergic asthma that
are inadequately controlled. Airway mast cells (MCs) are critically involved in allergic airway …

PDE3-inhibitor enoximone prevented mechanical ventilation in patients with SARS-CoV-2 pneumonia

J Beute, P Boermans, B Benraad, J Telman… - Experimental lung …, 2021 - Taylor & Francis
Background Standard care in severe SARS-CoV-2 pneumonia complicated by severe
dyspnea and respiratory failure, consists of symptom reduction, ultimately supported by …

Solubility Determination and Modeling for Milrinone in Binary Solvent Mixtures of Ethanol, Isopropanol, Ethylene Glycol, and N,N-Dimethylformamide + Water

J Zhang, X Song, R Xu - Journal of Chemical & Engineering Data, 2020 - ACS Publications
The equilibrium solubility of milrinone in the solvent mixtures of ethanol+ water,
isopropanol+ water, N, N-dimethylformamide (DMF)+ water, and ethylene glycol (EG)+ water …

Milrinone solubility in aqueous cosolvent solutions revisited: Inter/intra-molecular interactions, enthalpy-entropy compensation, and preferential solvation

Z Wang, Y Qian, A Farajtabar - Journal of Molecular Liquids, 2022 - Elsevier
Abstract Analysis of molecular electrostatic potential surface and Hirshfeld surface were
severally employed here to probe into the overall charge distribution and inter/intra …

Evaluation of Real‐Life Investigational Use of Enoximone in Asthma, the Third Step in Drug Repurposing: A Preliminary Report

J Beute, P Boermans, A KleinJan - Canadian Respiratory …, 2021 - Wiley Online Library
Background. The population of uncontrolled asthma patients represents a large therapeutic
burden. The PDE3‐inhibitor enoximone is a strong and quick bronchodilator and is known to …

[HTML][HTML] Oral enoximone allows the reduction and discontinuation of inhaled steroids and beta2 agonists in asthmatic children

J Beute, A KleinJan - International Journal of Pediatrics and Adolescent …, 2022 - Elsevier
In the last two decades, improvement on asthma treatment has been merely marginal for
both adults and children; inhaled corticosteroids (ICS) combined with β-2-mimetics remain …

(Oral) enoximone in asthma

J Beute - ERJ Open Research, 2020 - Eur Respiratory Soc
The Enoximone in status asthmaticus letter [1] referenced our case series from the
Netherlands wherein intravenous enoximone (Perfan, Carinopharm, Germany) reversed …