Actin is a key structural protein that makes up the cytoskeleton of cells, and plays a role in
functions such as division, migration, and vesicle trafficking. It comprises six different cell …

Cancer is a pathology characterized by a loss or a perturbation of a number of typical
features of normal cell behaviour. Indeed, the acquisition of an inappropriate migratory and …

Oxymatrine (OMT) is a quinolizidine alkaloid derived from the roots of the Sophora genus
plants. It has been widely used as a treatment for chronic hepatitis infections and …

Cancer cell migration is a plastic and adaptive process integrating cytoskeletal dynamics,
cell–extracellular matrix and cell–cell adhesion, as well as tissue remodeling. In response to …

Gentamicin is an aminoglycoside antibiotic commonly used to treat Gram-negative bacterial
infections that possesses considerable nephrotoxicity. Oxymatrine is a phytochemical with …

The effects of N-terminal acetylation of the high molecular weight tropomyosin isoforms
Tpm1. 6 and Tpm2. 1 and the low molecular weight isoforms Tpm1. 12, Tpm3. 1, and Tpm4 …

Phenotypic plasticity, defined as the ability of individual cells with stable genotypes to exert
different phenotypes upon exposure to specific environmental cues, represent the …

Mechanical force generation plays an essential role in many cellular functions, including
mitosis. Actomyosin contractile forces mediate changes in cell shape in mitosis and are …

Tropomyosin is the archetypal-coiled coil, yet studies of its structure and function have
proven it to be a dynamic regulator of actin filament function in muscle and non-muscle cells …

Tropomyosin (Tpm) is an α helical coiled-coil dimer that forms a co-polymer along the actin
filament. Tpm is involved in the regulation of actin's interaction with binding proteins as well …