Store-operated calcium channels
M Prakriya, RS Lewis - Physiological reviews, 2015 - journals.physiology.org
Store-operated calcium channels (SOCs) are a major pathway for calcium signaling in
virtually all metozoan cells and serve a wide variety of functions ranging from gene …
virtually all metozoan cells and serve a wide variety of functions ranging from gene …
Diseases caused by mutations in ORAI1 and STIM1
Ca2+ release‐activated Ca2+ (CRAC) channels mediate a specific form of Ca2+ influx
called store‐operated Ca2+ entry (SOCE) that contributes to the function of many cell types …
called store‐operated Ca2+ entry (SOCE) that contributes to the function of many cell types …
STIM proteins: dynamic calcium signal transducers
Stromal interaction molecule (STIM) proteins function in cells as dynamic coordinators of
cellular calcium (Ca2+) signals. Spanning the endoplasmic reticulum (ER) membrane, they …
cellular calcium (Ca2+) signals. Spanning the endoplasmic reticulum (ER) membrane, they …
Store-operated calcium entry: Mechanisms and modulation
PG Hogan, A Rao - Biochemical and biophysical research communications, 2015 - Elsevier
Store-operated calcium entry is a central mechanism in cellular calcium signalling and in
maintaining cellular calcium balance. This review traces the history of research on store …
maintaining cellular calcium balance. This review traces the history of research on store …
Omnitemporal choreographies of all five STIM/Orai and IP3Rs underlie the complexity of mammalian Ca2+ signaling
SM Emrich, RE Yoast, P Xin, V Arige, LE Wagner… - Cell reports, 2021 - cell.com
Summary Stromal-interaction molecules (STIM1/2) sense endoplasmic reticulum (ER) Ca 2+
depletion and activate Orai channels. However, the choreography of interactions between …
depletion and activate Orai channels. However, the choreography of interactions between …
The native ORAI channel trio underlies the diversity of Ca2+ signaling events
RE Yoast, SM Emrich, X Zhang, P Xin… - Nature …, 2020 - nature.com
The essential role of ORAI1 channels in receptor-evoked Ca2+ signaling is well understood,
yet little is known about the physiological activation of the ORAI channel trio natively …
yet little is known about the physiological activation of the ORAI channel trio natively …
Activating mutations in STIM1 and ORAI1 cause overlapping syndromes of tubular myopathy and congenital miosis
V Nesin, G Wiley, M Kousi, EC Ong… - Proceedings of the …, 2014 - National Acad Sciences
Signaling through the store-operated Ca2+ release-activated Ca2+ (CRAC) channel
regulates critical cellular functions, including gene expression, cell growth and …
regulates critical cellular functions, including gene expression, cell growth and …
Store-operated calcium channels: from function to structure and back again
RS Lewis - Cold Spring Harbor perspectives in biology, 2020 - cshperspectives.cshlp.org
Store-operated calcium (Ca2+) entry (SOCE) occurs through a widely distributed family of
ion channels activated by the loss of Ca2+ from the endoplasmic reticulum (ER). The best …
ion channels activated by the loss of Ca2+ from the endoplasmic reticulum (ER). The best …
An apical Phe-His pair defines the Orai1-coupling site and its occlusion within STIM1
Ca2+ signal-generation through inter-membrane junctional coupling between endoplasmic
reticulum (ER) STIM proteins and plasma membrane (PM) Orai channels, remains a vital but …
reticulum (ER) STIM proteins and plasma membrane (PM) Orai channels, remains a vital but …
STIM1/Orai1 coiled-coil interplay in the regulation of store-operated calcium entry
Orai1 calcium channels in the plasma membrane are activated by stromal interaction
molecule-1 (STIM1), an endoplasmic reticulum calcium sensor, to mediate store-operated …
molecule-1 (STIM1), an endoplasmic reticulum calcium sensor, to mediate store-operated …