Monogenic intestinal epithelial disorders, also known as congenital diarrheas and
enteropathies (CoDEs), are a group of rare diseases that result from mutations in genes that …

Tuft cells are a rare and morphologically distinct chemosensory cell type found throughout
many organs, including the gastrointestinal tract. These cells were identified by their unique …

Microvillus inclusion disease (MVID), caused by loss-of-function mutations in the motor
protein myosin Vb (MYO5B), is a severe infantile disease characterized by diarrhea …

Digestive system diseases arise primarily through the interplay of genetic and environmental
influences; there is an urgent need in elucidating the pathogenic mechanisms of these …

Functional loss of the motor protein myosin Vb (MYO5B) induces various defects in intestinal
epithelial function and causes a congenital diarrheal disorder, namely, microvillus inclusion …

The gut microbiota plays a crucial role in maintaining epithelial barrier function. Although
multiple studies have demonstrated the significance of dietary factors on the gut microbiota …

In addition to the small intestine's well-known function of nutrient absorption, the small
intestine also plays a major role in nutrient sensing. Similar to taste sensors seen on the …

Monogenetic variants are responsible for a range of congenital human diseases. Variants in
genes that are important for intestinal epithelial function cause a group of disorders …

Listeria monocytogenes (Lm) is a food-borne pathogen that causes severe bacterial
gastroenteritis, with high rates of hospitalization and mortality. Lm is ubiquitous in soil, water …

Microvillus inclusion disease (MVID) is a congenital diarrheal disorder resulting in life-
threatening secretory diarrhea in newborns. Inactivating and nonsense mutations in myosin …