What can we learn when fitting a simple telegraph model to a complex gene expression model?
F Jiao, J Li, T Liu, Y Zhu, W Che… - PLOS Computational …, 2024 - journals.plos.org
In experiments, the distributions of mRNA or protein numbers in single cells are often fitted to
the random telegraph model which includes synthesis and decay of mRNA or protein, and …
the random telegraph model which includes synthesis and decay of mRNA or protein, and …
Stochastic transcription with alterable synthesis rates
C Zhu, Z Chen, Q Sun - Mathematics, 2022 - mdpi.com
Background: Gene transcription is a random bursting process that leads to large variability in
mRNA numbers in single cells. The main cause is largely attributed to random switching …
mRNA numbers in single cells. The main cause is largely attributed to random switching …
[PDF][PDF] THE DYNAMICS OF GENE TRANSCRIPTION INDUCED BY VARIATION IN TRANSCRIPTION KINETICS
H Fang, Q Sun - Journal of Applied Analysis & Computation, 2023 - jaac-online.com
In single cells, the process of gene transcription generally demonstrates complicated and
stochastic behaviors. The stochasticity of transcription brings about large variations in the …
stochastic behaviors. The stochasticity of transcription brings about large variations in the …