Excitotoxicity is a phenomenon that describes the toxic actions of excitatory
neurotransmitters, primarily glutamate, where the exacerbated or prolonged activation of …

Mounting evidence suggests that acute and chronic stress, especially the stress-induced
release of glucocorticoids, induces changes in glutamate neurotransmission in the prefrontal …

System xc‐is an amino acid antiporter that typically mediates the exchange of extracellular l‐
cystine and intracellular l‐glutamate across the cellular plasma membrane. Studied in a …

Schizophrenia is a devastating neurodevelopmental disorder whose genetic influences
remain elusive. We hypothesize that individually rare structural variants contribute to the …

l-Glutamate is the predominant excitatory neurotransmitter in the mammalian central
nervous system and plays important roles in a wide variety of brain functions, but it is also a …

The mammalian genome contains four genes encoding GABA transporters (GAT1, slc6a1;
GAT2, slc6a13; GAT3, slc6a11; BGT1, slc6a12) and five glutamate transporter genes …

Glutamate is an essential excitatory neurotransmitter regulating brain functions. Excitatory
amino acid transporter (EAAT)‐2 is one of the major glutamate transporters expressed …

This introductory article to the special edition on glutamate neurotransmission in
neuropsychiatric disorders provides an overview of glutamate neurotransmitter system …

Clinical management of chronic pain after nerve injury (neuropathic pain) and tumor
invasion (cancer pain) is a real challenge due to our limited understanding of the cellular …

Neither normal brain function nor the pathological processes involved in neurological
diseases can be adequately understood without knowledge of the release, uptake and …