Understanding microRNA-mediated gene regulatory networks through mathematical modelling

X Lai, O Wolkenhauer, J Vera - Nucleic acids research, 2016 - academic.oup.com
The discovery of microRNAs (miRNAs) has added a new player to the regulation of gene
expression. With the increasing number of molecular species involved in gene regulatory …

Integrated omics: tools, advances and future approaches

BB Misra, C Langefeld, M Olivier… - Journal of molecular …, 2019 - jme.bioscientifica.com
With the rapid adoption of high-throughput omic approaches to analyze biological samples
such as genomics, transcriptomics, proteomics, and metabolomics, each analysis can …

A guide to micro RNA‐mediated gene silencing

M Quévillon Huberdeau, MJ Simard - The FEBS journal, 2019 - Wiley Online Library
As an important regulator of gene expression in eukaryotes, micro RNA s (mi RNA s) have
been subject to extensive research to understand their pleiotropic roles in development and …

Efficient 3′-pairing renders microRNA targeting less sensitive to mRNA seed accessibility

DM Kosek, E Banijamali, W Becker… - Nucleic Acids …, 2023 - academic.oup.com
MicroRNAs (miRNAs) are short RNAs that post-transcriptionally regulate gene expression
by binding to specific sites in mRNAs. Site recognition is primarily mediated by the seed …

Literature review of baseline information to support the risk assessment of RNA i‐based GM plants

J Paces, M Nic, T Novotny… - EFSA Supporting …, 2017 - Wiley Online Library
This report is the outcome of an EFSA procurement aiming at investigating and summarising
the state of knowledge on (I) the mode-of-action of dsRNA and miRNA pathways,(II) the …

The sequence features that define efficient and specific hAGO2-dependent miRNA silencing guides

Y Yan, M Acevedo, L Mignacca… - Nucleic acids …, 2018 - academic.oup.com
MicroRNAs (miRNAs) are ribonucleic acids (RNAs) of∼ 21 nucleotides that interfere with
the translation of messenger RNAs (mRNAs) and play significant roles in development and …

Human MicroRNA target prediction via multi-hypotheses learning

M Mohebbi, L Ding, RL Malmberg… - Journal of Computational …, 2021 - liebertpub.com
MicroRNAs are involved in many critical cellular activities through binding to their mRNA
targets, for example, in cell proliferation, differentiation, death, growth control, and …

Systemic CLIP-seq analysis and game theory approach to model microRNA mode of binding

F Serra, S Bottini, D Pratella… - Nucleic Acids …, 2021 - academic.oup.com
Abstract microRNAs (miRNAs) associate with Ago proteins to post-transcriptionally silence
gene expression by targeting mRNAs. To characterize the modes of miRNA-binding, we …

MicroRNA and Nonsense Transcripts as Putative Viral Evasion Mechanisms

AA Bakre, A Maleki, RA Tripp - Frontiers in Cellular and Infection …, 2019 - frontiersin.org
Viral proteins encode numerous antiviral activities to modify the host immunity. In this article,
we hypothesize that viral genomes and gene transcripts interfere with host gene expression …

Canada's contributions to RNA research: past, present and future perspectives

E Lécuyer, M Sauvageau, U Kothe, PJ Unrau… - 2024 - tspace.library.utoronto.ca
The field of RNA research has provided profound insights into the basic mechanisms
modulating the function and adaption of biological systems. RNA has also been at the center …