Transcription factors are involved in a large number of human diseases such as cancers for
which they account for about 20% of all oncogenes identified so far. For long time, with the …

The mixed-lineage leukemia 1 (MLL1) gene (now renamed Lysine [K]-specific
MethylTransferase 2A or KMT2A) on chromosome 11q23 is disrupted in a unique group of …

The concept of differentiation therapy emerged from the fact that hormones or cytokines may
promote differentiation ex vivo, thereby irreversibly changing the phenotype of cancer cells …

Histone deacetylases (HDACs) are a key component of the epigenetic machinery regulating
gene expression, and behave as oncogenes in several cancer types, spurring the …

To separate causal effects of histone acetylation on chromatin accessibility and
transcriptional output, we used integrated epigenomic and transcriptomic analyses following …

Heterobifunctional proteolysis-targeting chimeric compounds leverage the activity of E3
ligases to induce degradation of target oncoproteins and exhibit potent preclinical antitumor …

Programmed cell-death protein 1 (PD-1) and programmed death-ligand 1 (PD-L1) pathway
blockade is a promising therapy for the treatment of advanced cancers, including B-cell …

Lack of cellular differentiation is a hallmark of many human cancers, including acute myeloid
leukemia (AML). Strategies to overcome such a differentiation blockade are an approach for …

As “Michael acceptors” may induce promiscuous responses in mammalian cells by reacting
with various proteins, we modified the cinnamamide of our previous hydrazide-based HDAC …

Cancer cell hallmarks are underpinned by transcriptional programmes operating in the
context of a dynamic and complicit epigenomic environment. Somatic alterations of …