A hallmark of retroviral replication is establishment of the proviral state, wherein a DNA copy
of the viral RNA genome is stably incorporated into a host cell chromosome. Integrase is the …

The capsid (CA) protein of the human immunodeficiency virus type 1 (HIV-1) is an essential
structural component of a virion and facilitates many crucial life cycle steps through …

Summary Human immunodeficiency virus (HIV-1) remains a major health threat. Viral capsid
uncoating and nuclear import of the viral genome are critical for productive infection. The …

Retroviral infection involves the reverse transcription of the viral RNA genome into DNA,
which is subsequently integrated into the host cell genome. Human immunodeficiency virus …

HIV-1 replication commences inside the cone-shaped viral capsid, but timing, localization,
and mechanism of uncoating are under debate. We adapted a strategy to visualize …

Nuclear entry of HIV-1 replication complexes through intact nuclear pore complexes is
critical for successful infection. The host protein cleavage-and-polyadenylation-specificity …

People living with HIV (PLWH) have expressed concern about the life-long burden and
stigma associated with taking pills daily and can experience medication fatigue that might …

After invasion of a susceptible target cell, HIV-1 completes the early phase of its life cycle
upon integration of reverse-transcribed viral DNA into host chromatin. The viral capsid, a …

The study of the Nuclear Pore Complex (NPC), the proteins that compose it (nucleoporins),
and the nucleocytoplasmic transport that it controls have revealed an unexpected layer to …

Small molecules that bind to the viral capsid protein can be potent inhibitors of HIV infection.
Capsid-targeting drugs are predicted to exhibit high barriers to viral resistance, and ongoing …