Advances in genotyping and sequencing technologies, coupled with the development of
sophisticated statistical methods, have afforded investigators novel opportunities to define …

Haplotype phase information in diploid organisms provides valuable information on human
evolutionary history and may lead to the development of more efficient strategies to identify …

The program phase is widely used for Bayesian inference of haplotypes from diploid
genotypes; however, manually creating phase input files from sequence alignments is an …

To control for hidden population stratification in genetic-association studies, statistical
methods that use marker genotype data to infer population structure have been proposed as …

Demographic events affect all genes in a genome, whereas natural selection has only local
effects. Using publicly available data from 151 loci sequenced in both European-American …

It is now widely accepted that haplotypic information can be of great interest for investigating
the role of a candidate gene in the etiology of complex diseases. In the absence of family …

An extraordinarily large number of single nucleotide polymorphisms (SNPs) are now
available in humans as well as in other model organisms. Technological advancements may …

Nuclear sequence data, often from multiple loci, are increasingly being employed in
analyses of population structure and history, yet there has been relatively little evaluation of …

Recent studies have suggested that a significant fraction of the human genome is contained
in blocks of strong linkage disequilibrium, ranging from∼ 5 to> 100 kb in length, and that …

Interest in the assignment and frequency analysis of haplotypes in samples of unrelated
individuals has increased immeasurably as a result of the emphasis placed on haplotype …