Anti-inflammatory therapy for COVID-19 infection: the case for colchicine

AZ Reyes, KA Hu, J Teperman… - Annals of the …, 2021 - ard.bmj.com
The search for effective COVID-19 management strategies continues to evolve. Current
understanding of SARS-CoV-2 mechanisms suggests a central role for exaggerated …

Antimicrobial peptides: general overview and clinical implications in human health and disease

E Guaní-Guerra, T Santos-Mendoza, SO Lugo-Reyes… - Clinical …, 2010 - Elsevier
Antimicrobial peptides (AMPs) are evolutionarily conserved molecules involved in the
defense mechanisms of a wide range of organisms. Produced in bacteria, insects, plants …

Icariin protects podocytes from NLRP3 activation by Sesn2-induced mitophagy through the Keap1-Nrf2/HO-1 axis in diabetic nephropathy

X Ding, H Zhao, C Qiao - Phytomedicine, 2022 - Elsevier
Background Icariin (ICA) is a flavonoid extract obtained from Herba epimedii that has been
proven to exert multiple pharmacological activities, including antifibrotic and anti …

Alarmins link neutrophils and dendritic cells

D Yang, G de la Rosa, P Tewary, JJ Oppenheim - Trends in immunology, 2009 - cell.com
Neutrophils are the first major population of leukocyte to infiltrate infected or injured tissues
and are crucial for initiating host innate defense and adaptive immunity. Although the …

Antimicrobial host defence peptides: immunomodulatory functions and translational prospects

AM van der Does, PS Hiemstra… - … Peptides: Basics for …, 2019 - Springer
Cationic host defence peptides (CHDPs), also known as antimicrobial peptides, exhibit a
wide range of activities contributing to immune responses and resolution of infections …

Cathelicidin-related antimicrobial peptide protects against myocardial ischemia/reperfusion injury

Y Bei, LL Pan, Q Zhou, C Zhao, Y Xie, C Wu, X Meng… - BMC medicine, 2019 - Springer
Background Cathelicidins are a major group of natural antimicrobial peptides which play
essential roles in regulating host defense and immunity. In addition to the antimicrobial and …

Neutrophil α-defensins promote thrombosis in vivo by altering fibrin formation, structure, and stability

R Abu-Fanne, V Stepanova, RI Litvinov… - Blood, The Journal …, 2019 - ashpublications.org
Inflammation and thrombosis are integrated, mutually reinforcing processes, but the
interregulatory mechanisms are incompletely defined. Here, we examined the contribution of …

Alterations of the salivary secretory peptidome profile in children affected by type 1 diabetes

T Cabras, E Pisano, A Mastinu, G Denotti… - Molecular & Cellular …, 2010 - ASBMB
The acidic soluble fraction of whole saliva of type 1 diabetic children was analyzed by
reversed phase (RP) 1 1The abbreviations used are: aPRPssalivary acidic proline-rich …

Alterations in gut microbiota and host transcriptome of patients with coronary artery disease

L Chen, X Mou, J Li, M Li, C Ye, X Gao, X Liu, Y Ma… - BMC microbiology, 2023 - Springer
Background Coronary artery disease (CAD) is a widespread heart condition caused by
atherosclerosis and influences millions of people worldwide. Early detection of CAD is …

Neutrophil (dys) function due to altered immuno-metabolic axis in type 2 diabetes: implications in combating infections

PY Thimmappa, S Vasishta, K Ganesh, AS Nair… - Human Cell, 2023 - Springer
Metabolic and inflammatory pathways are highly interdependent, and both systems are
dysregulated in Type 2 diabetes (T2D). T2D is associated with pre-activated inflammatory …