The ability of 2-deoxy-d-glucose (2-DG) to interfere with d-glucose metabolism demonstrates
that nutrient and energy deprivation is an efficient tool to suppress cancer cell growth and …

Hypoxia is a feature of most tumours, albeit with variable incidence and severity within a
given patient population. It is a negative prognostic and predictive factor owing to its multiple …

Research over the past decade has extended the prevailing view of the mitochondrion to
include functions well beyond the generation of cellular energy. It is now recognized that …

The prognosis with pancreatic cancer is among the poorest of any human cancer. One of the
important factors is the tumor hypoxia. Targeting tumor hypoxia is considered a desirable …

Tumors have long been known to rewire their metabolism to endorse their proliferation,
growth, survival, and invasiveness. One of the common characteristics of these alterations is …

Redox dysregulation originating from metabolic alterations and dependence on mitogenic
and survival signaling through reactive oxygen species represents a specific vulnerability of …

Increased aerobic glycolysis in cancer, a phenomenon known as the Warburg effect, has
been observed in various tumor cells and represents a major biochemical alteration …

Viral infection almost invariably causes metabolic changes in the infected cell and several
types of host cells that respond to the infection. Among metabolic changes, the most …

In tumor cells growing under hypoxia, inhibiting glycolysis with 2-deoxy-d-glucose (2-DG)
leads to cell death, whereas under normoxic conditions cells similarly treated survive …

One of the key factors that correlates with poor survival of patients with pancreatic cancer is
the extent of hypoxic areas within the tumor tissue. The adaptation of pancreatic cancer cells …