Hypertension is a global public health issue and the leading cause of premature death in
humans. Despite more than a century of research, hypertension remains difficult to cure due …

Vascular ageing, characterized by structural and functional changes in blood vessels of
which arterial stiffness and endothelial dysfunction are key components, is associated with …

The authors hypothesized that the cytokine storm described in COVID-19 patients may lead
to consistent cell-based tissue factor (TF)-mediated activation of coagulation, procoagulant …

For the treatment of systemic hypertension, pharmacological intervention in nitric oxide-
cyclic guanosine monophosphate signaling is a well-explored but unexploited option. In this …

Mechanism-based therapy centred on the molecular understanding of disease-causing
pathways in a given patient is still the exception rather than the rule in medicine, even in …

Oxidative stress and chronic inflammation play an important role in the pathogenesis of
atherosclerosis. Atherosclerosis develops as the first step of vascular endothelial …

HMG-CoA reductase (HMGCR) is the rate-limiting enzyme in cholesterol de novo
biosynthesis and its degradation may bring therapeutic benefits for the treatment of …

Persistently unrepaired DNA damage has been identified as a causative factor for vascular
ageing. We have previously shown that a defect in the function or expression of the DNA …

DNA damage is a causative factor in ageing of the vasculature and other organs. One of the
most important vascular ageing features is reduced nitric oxide (NO) soluble guanylate …

Nitric oxide (NO)(co) regulates many physiological processes in the body. Its short-lived free
radicals force synthesis in situ and on-demand, without storage possibility. Local oxygen …