Neuromodulation of spike-timing-dependent plasticity: past, present, and future

Z Brzosko, SB Mierau, O Paulsen - Neuron, 2019 - cell.com
Spike-timing-dependent synaptic plasticity (STDP) is a leading cellular model for behavioral
learning and memory with rich computational properties. However, the relationship between …

[HTML][HTML] Amygdala activity and amygdala-hippocampus connectivity: metabolic diseases, dementia, and neuropsychiatric issues

J Song - Biomedicine & Pharmacotherapy, 2023 - Elsevier
With rapid aging of the population worldwide, the number of people with dementia is
dramatically increasing. Some studies have emphasized that metabolic syndrome, which …

Deep brain stimulation by blood–brain-barrier-crossing piezoelectric nanoparticles generating current and nitric oxide under focused ultrasound

T Kim, HJ Kim, W Choi, YM Lee, JH Pyo, J Lee… - Nature Biomedical …, 2023 - nature.com
Deep brain stimulation via implanted electrodes can alleviate neuronal disorders. However,
its applicability is constrained by side effects resulting from the insertion of electrodes into …

Conditional and unconditional components of aversively motivated freezing, flight and darting in mice

JM Trott, AN Hoffman, I Zhuravka, MS Fanselow - Elife, 2022 - elifesciences.org
Fear conditioning is one of the most frequently used laboratory procedures for modeling
learning and memory generally, and anxiety disorders in particular. The conditional …

Quantified coexpression analysis of central amygdala subpopulations

KM McCullough, FG Morrison, J Hartmann… - eneuro, 2018 - eneuro.org
Molecular identification and characterization of fear controlling circuitries is a promising path
towards developing targeted treatments of fear-related disorders. Three-color in situ …

Amygdala intercalated cells: gate keepers and conveyors of internal state to the circuits of emotion

D Asede, D Doddapaneni… - Journal of Neuroscience, 2022 - Soc Neuroscience
Generating adaptive behavioral responses to emotionally salient stimuli requires evaluation
of complex associations between multiple sensations, the surrounding context, and current …

A neuronal basis for fear discrimination in the lateral amygdala

A Grosso, G Santoni, E Manassero, A Renna… - Nature …, 2018 - nature.com
In the presence of new stimuli, it is crucial for survival to react with defensive responses in
the presence of stimuli that resemble threats but also to not react with defensive behavior in …

The neural circuits and molecular mechanisms underlying fear dysregulation in posttraumatic stress disorder

J Iqbal, GD Huang, YX Xue, M Yang… - Frontiers in Neuroscience, 2023 - frontiersin.org
Post-traumatic stress disorder (PTSD) is a stress-associated complex and debilitating
psychiatric disorder due to an imbalance of neurotransmitters in response to traumatic …

Dopaminergic regulation of nucleus accumbens cholinergic interneurons demarcates susceptibility to cocaine addiction

JH Lee, EA Ribeiro, J Kim, B Ko, H Kronman… - Biological …, 2020 - Elsevier
Abstract Background Cholinergic interneurons (ChINs) in the nucleus accumbens (NAc)
play critical roles in processing information related to reward. However, the contribution of …

Amygdala circuits for fear memory: a key role for dopamine regulation

JH Lee, S Lee, JH Kim - The Neuroscientist, 2017 - journals.sagepub.com
In addition to modulating a number of cognitive functions including reward, punishment,
motivation, and salience, dopamine (DA) plays a pivotal role in regulating threat-related …