Homozygous ALS-linked FUS P525L mutations cell-autonomously perturb transcriptome profile and chemoreceptor signaling in human iPSC microglia

SY Kerk, Y Bai, J Smith, P Lalgudi, C Hunt, J Kuno… - Stem Cell Reports, 2022 - cell.com
Amyotrophic lateral sclerosis is a fatal disease pathologically typified by motor and cortical
neurodegeneration as well as microgliosis. The FUS P525L mutation is highly penetrant and …